Description

Insulin, (2-Nitro-4-Azidophenylacetyl) (B29)- CAS NO 76688-25-0 is a chemically modified insulin derivative, specifically functionalized at the B29 lysine residue with a photoreactive 2-nitro-4-azidophenylacetyl group. This compound is a critical research-grade biochemical tool designed for advanced proteomic and structural biology studies. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotech companies specializing in diabetes research, insulin receptor mapping, and photochemical cross-linking applications.

Application

• Photochemical Cross-linking Studies: Used as a photoaffinity label to covalently tag and identify insulin receptor subunits and binding sites.
• Insulin Receptor Mapping: Essential for probing the three-dimensional structure and interaction dynamics of the insulin-receptor complex.
• Biochemical Research: Serves as a key intermediate in the development of novel insulin analogs and targeted drug delivery systems.
• Proteomics: Employed in mass spectrometry-based workflows to study protein-protein interactions involving insulin signaling pathways.
• Method Development: Used in academic and industrial labs to develop and validate new analytical techniques for modified peptide analysis.

Basic Information

Product Name	Insulin, (2-Nitro-4-Azidophenylacetyl) (B29)- CAS NO 76688-25-0
CAS No.	76688-25-0
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	NεB29-(2-Nitro-4-azidophenylacetyl)insulin; B29-(2-Nitro-4-azidophenylacetyl)-Insulin; 2-Nitro-4-azidophenylacetyl-insulin (B29); Insulin, B29-modified; Photoaffinity Insulin Derivative; Insulin Photoaffinity Label; NAP-A-insulin; Azidophenylacetyl Insulin
EINECS	Contact for details

Quality Control

Our research-grade biochemicals are produced and handled under strict quality control protocols to ensure batch-to-batch consistency and reliability for sensitive applications. Each lot is characterized using advanced analytical techniques including HPLC and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and functional performance is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0 %
Biological Activity	Assessed by receptor binding assay
Solubility	Soluble in DMSO, dilute acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.