Description

Fluphenazine 4-Chlorophenoxyisobutyrate Ester is a key pharmaceutical intermediate and a long-acting ester derivative of the antipsychotic agent fluphenazine. This compound is critical for the development and manufacturing of depot injection formulations, which provide sustained therapeutic release for improved patient compliance in chronic treatment regimens. It is primarily utilized by advanced pharmaceutical manufacturers and research institutions specializing in neuropsychiatric therapeutics.

Application

• Active Pharmaceutical Ingredient (API) Intermediate: Serves as a crucial precursor in the synthesis of fluphenazine decanoate and other long-acting ester prodrugs.
• Sustained-Release Formulations: Used in the development of oil-based depot injections for the management of schizophrenia and other psychotic disorders.
• Pharmaceutical Research & Development: Employed in preclinical and clinical studies to investigate the pharmacokinetics of esterified neuroleptic agents.
• Process Chemistry & Scale-Up: A vital building block for process chemists during the optimization and commercial-scale manufacturing of antipsychotic medications.
• Reference Standard: Can be utilized as a chromatographic reference standard for quality control and analytical method development.

Basic Information

Product Name	Fluphenazine 4-Chlorophenoxyisobutyrate Ester
CAS No.	76674-42-5
Molecular Formula	C28H26ClF3N3O3S
Molecular Weight	576.04 g/mol
Synonyms	Fluphenazine 4-Chlorophenoxyisobutyrate; Fluphenazine 4-Chlorophenoxyisobutyric Acid Ester; 2-[4-[3-[2-(Trifluoromethyl)-10H-phenothiazin-10-yl]propyl]piperazin-1-yl]ethyl 4-chlorophenoxyisobutyrate; 4-Chlorophenoxyisobutyric Acid Fluphenazine Ester; Fluphenazine Isobutyrate Ester; NSC 338258
EINECS	Contact for details

Quality Control

Our Fluphenazine 4-Chlorophenoxyisobutyrate Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the stringent requirements for pharmaceutical intermediate use. Certificates of Analysis (COA) documenting full specifications are available upon request, supporting compliance with cGMP and ICH Q7 guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The material is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.