Description

Naltrexone-3-Glucuronide is a major, pharmacologically active metabolite of the opioid antagonist naltrexone. This compound is of critical importance for pharmaceutical research and development, particularly in the study of drug metabolism, pharmacokinetics, and the development of analytical standards. It is primarily utilized by research institutions, pharmaceutical companies, and contract research organizations (CROs) engaged in bioanalytical method development and clinical studies related to substance dependence treatments.

Application

• Pharmaceutical Reference Standard: Serves as a certified reference material (CRM) for the quantitative and qualitative analysis of naltrexone and its metabolites in biological matrices.
• Bioanalytical Research: Essential for developing and validating HPLC, LC-MS, and GC-MS methods in pharmacokinetic and pharmacodynamic studies.
• Metabolite Identification & Profiling: Used in ADME (Absorption, Distribution, Metabolism, Excretion) studies to understand the metabolic pathways of naltrexone.
• Clinical Trial Support: Employed as a calibration standard in clinical laboratories monitoring naltrexone compliance and exposure levels in patients.
• Forensic Toxicology: Acts as a key analytical standard in forensic labs for the precise detection and confirmation of naltrexone use.
• Drug Development & Formulation: Supports research into novel formulations and delivery systems for opioid antagonists.

Basic Information

Product Name	Naltrexone-3-Glucuronide
CAS No.	76630-71-2
Molecular Formula	C25H33NO9
Molecular Weight	491.53 g/mol
Synonyms	17-(Cyclopropylmethyl)-4,5α-epoxy-3,14-dihydroxymorphinan-6-one 3-β-D-Glucuronide; Naltrexone 3-β-D-Glucuronide; Naltrexone Glucuronide; Naltrexone 3-Gluc; 6-Ketonaltrexone 3-Glucuronide; Noroxymorphone glucuronide derivative; UNII-8M5F0I16QN
EINECS	Contact for details

Quality Control

Our Naltrexone-3-Glucuronide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis to ensure it meets the stringent requirements for research and reference standards. A detailed Certificate of Analysis (COA) providing batch-specific data is supplied with every order.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.