Description

Fmoc-Leu-Osu CAS NO 76542-83-1 is a high-purity, activated ester derivative of the amino acid leucine, protected with a 9-fluorenylmethoxycarbonyl (Fmoc) group. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the efficient and controlled incorporation of leucine residues. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors who require reliable, high-quality reagents for peptide and protein research, drug discovery, and the development of therapeutic peptides.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key reagent for the automated, stepwise synthesis of peptides using Fmoc-chemistry protocols.
• Peptide Drug Development: Used in the research and production of therapeutic peptides and peptidomimetics for various disease targets.
• Bioconjugation: Facilitates the site-specific labeling or modification of peptides, proteins, and other biomolecules.
• Combinatorial Chemistry: Employed in the generation of peptide libraries for high-throughput screening in drug discovery.
• Academic & Industrial Research: A fundamental tool for studying protein structure-function relationships, enzyme substrates, and receptor ligands.
• Custom Peptide Service Providers: A staple raw material for companies offering bespoke peptide synthesis services.

Basic Information

Product Name	Fmoc-Leu-Osu
CAS No.	76542-83-1
Molecular Formula	C22H22N2O6
Molecular Weight	410.42 g/mol
Synonyms	Fmoc-L-leucine N-hydroxysuccinimide ester; N-(9-Fluorenylmethoxycarbonyl)-L-leucine N-succinimidyl ester; Fmoc-Leu-OSu; Fmoc-L-Leu-OSu; Nα-Fmoc-L-leucine succinimidyl ester; (9H-Fluoren-9-yl)methyl (2S)-4-methyl-1-[(2,5-dioxopyrrolidin-1-yl)oxy]-1-oxopentan-2-ylcarbamate; Fmoc-Leu-O-NHS; Fmoc-Leu-NHS ester
EINECS	Contact for details

Quality Control

Our Fmoc-Leu-Osu is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for sensitive research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to industry best practices and can provide material traceable to relevant standards upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C to -10°C under desiccant. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥98.0%
Optical Rotation	-15.0° to -18.0° (c=1 in DMF)
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.