Description

Boc-D-Lys(Z)-Oh CAS NO 76477-42-4 is a protected derivative of the D-isomer of the amino acid lysine, featuring both Boc (tert-butoxycarbonyl) and Z (benzyloxycarbonyl) protecting groups. This dual-protected building block is critical for the controlled synthesis of complex peptides and peptidomimetics, ensuring regioselectivity and preventing unwanted side reactions during coupling steps. It is an essential intermediate for pharmaceutical researchers, medicinal chemists, and biotech companies engaged in the development of novel therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key chiral building block for the controlled, sequential assembly of custom peptides, particularly where the D-lysine residue is required.
• Pharmaceutical Intermediate: Used in the research and development of peptide-based drugs, including hormone analogs, antimicrobial peptides, and targeted therapeutics.
• Bioconjugation and Linker Chemistry: The orthogonal protecting groups allow for selective deprotection, making it valuable for creating peptide-drug conjugates or attaching peptides to surfaces and other molecules.
• Biochemical Research: Employed in the study of enzyme-substrate interactions, protein folding, and structure-activity relationships (SAR) due to its modified side chain.
• Production of Reference Standards: Serves as a high-purity standard for analytical method development and quality control in peptide manufacturing.

Basic Information

Product Name	Boc-D-Lys(Z)-Oh
CAS No.	76477-42-4
Molecular Formula	C₁₉H₂₈N₂O₆
Molecular Weight	380.44 g/mol
Synonyms	N2-[(1,1-Dimethylethoxy)carbonyl]-N6-[(phenylmethoxy)carbonyl]-D-lysine; D-Lysine, N2-[(1,1-dimethylethoxy)carbonyl]-N6-[(phenylmethoxy)carbonyl]-; Boc-D-Lys(Z)-OH; (R)-2-((tert-Butoxycarbonyl)amino)-6-((benzyloxycarbonyl)amino)hexanoic acid; Nα-Boc-Nε-Z-D-lysine; Boc-D-Lys(Boc)-OH (Note: Common mis-identification, correct protecting group is Z); N-Boc-N'-Z-D-lysine; D-Boc-Lys(Z)-OH
EINECS	Contact for details

Quality Control

Our Boc-D-Lys(Z)-Oh is manufactured under strict quality management systems to ensure batch-to-batch consistency and high chemical purity suitable for research and pharmaceutical applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles. We adhere to relevant industry standards and can provide material for GMP applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (D-isomer)
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Single Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.