Description

Deacetyltaxol B, 10-(Rg) CAS NO 76429-85-1 is a high-purity, semi-synthetic taxane derivative of significant interest in advanced pharmaceutical research. This compound serves as a crucial intermediate for the synthesis of novel anti-cancer agents and for structure-activity relationship (SAR) studies. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers focused on oncology drug discovery and development.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of next-generation taxane-based chemotherapeutic agents.
• Oncology Research: Used in biochemical and pharmacological studies to investigate mechanisms of action and improve therapeutic efficacy against various cancer cell lines.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical laboratories.
• SAR Studies: Essential for structure-activity relationship research to modify the taxane core for enhanced potency, reduced toxicity, or improved solubility.
• Process Chemistry: Employed in the development and scale-up of synthetic routes for complex anti-cancer active pharmaceutical ingredients (APIs).

Basic Information

Product Name	Deacetyltaxol B, 10-(Rg)
CAS No.	76429-85-1
Molecular Formula	C45H49NO14
Molecular Weight	827.88 g/mol
Synonyms	10-Deacetyl-7-epitaxol; 10-Deacetyl-7-epitaxol B; 10-Deacetylpaclitaxel B; 7-Epi-10-deacetyltaxol; 10-(Rg) Deacetyltaxol B; (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(Acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecah-6,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl (2R,3S)-3-(benzoylamino)-2-hydroxy-3-phenylpropanoate
EINECS	Contact for details

Quality Control

Our Deacetyltaxol B, 10-(Rg) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the stringent requirements for research and pharmaceutical development. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and light-sensitive; desiccants are recommended for long-term storage.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.