Description

Boc-D-Glu(Ome)-Oh is a protected derivative of D-glutamic acid, featuring a tert-butoxycarbonyl (Boc) group on the amine and a methyl ester on the side-chain carboxylic acid. This compound is a crucial chiral building block in the synthesis of complex peptides and peptidomimetics, offering precise stereochemical control and orthogonal protection strategies. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutic agents, diagnostic probes, and advanced biomaterials.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the solid-phase and solution-phase synthesis of peptide-based drugs and active pharmaceutical ingredients (APIs).
• Bioconjugation & Probe Development: Used in the preparation of labeled peptides for biochemical assays, imaging probes, and targeted drug delivery systems.
• Research & Development: Essential for academic and industrial R&D in medicinal chemistry for constructing peptide libraries and studying structure-activity relationships (SAR).
• Custom Peptide Synthesis: A fundamental starting material for contract research and manufacturing organizations (CROs/CMOs) producing custom peptides on gram to kilogram scale.
• Enzyme Substrate Analogues: Employed in the design and synthesis of inhibitors or substrates for glutamyl-specific proteases and other enzymes.

Basic Information

Product Name	Boc-D-Glu(Ome)-Oh
CAS No.	76379-02-7
Molecular Formula	C11H19NO6
Molecular Weight	261.27 g/mol
Synonyms	(2R)-2-[(tert-Butoxycarbonyl)amino]pentanedioic acid 5-methyl ester; D-Glutamic acid, N-(tert-butoxycarbonyl)-, 5-methyl ester; Boc-D-Glu(OMe)-OH; Boc-D-glutamic acid 5-methyl ester; N-Boc-D-glutamic acid 5-methyl ester; N-(tert-Butoxycarbonyl)-D-glutamic acid 5-methyl ester; (R)-2-((tert-Butoxycarbonyl)amino)pentanedioic acid 5-methyl ester
EINECS	Contact for details

Quality Control

Our Boc-D-Glu(Ome)-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical research and development. A Certificate of Analysis (COA) detailing specific results for identity, purity, and related substances is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (D-isomer)
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.