Description

Glucagon, 2-Nitro-4-Azidophenylsulfenyl- is a chemically modified derivative of the peptide hormone glucagon, designed for advanced biochemical research and development. This compound is a critical reagent for photoaffinity labeling and cross-linking studies, enabling the detailed mapping of hormone-receptor interactions and binding sites. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotech companies engaged in endocrinology, metabolic disease research, and novel therapeutic agent discovery.

Application

• Photoaffinity Labeling: Acts as a key probe for covalently tagging and identifying glucagon receptor proteins and their active sites.
• Structural Biology Studies: Used in cross-linking experiments to stabilize protein-ligand complexes for analysis via X-ray crystallography or cryo-EM.
• Drug Discovery Platforms: Serves as a tool compound in high-throughput screening assays to discover and characterize new glucagon receptor modulators.
• Metabolic Pathway Research: Employed to investigate the molecular mechanisms of glucagon signaling in liver cells and its role in glucose homeostasis.
• Bioconjugation & Probe Development: Provides a reactive handle (azido and sulfenyl groups) for creating fluorescent or affinity-tagged glucagon analogs.
• Antibody & Diagnostic Reagent Development: Can be used as a hapten to generate specific antibodies for immunoassays targeting glucagon or its receptor.

Basic Information

Product Name	Glucagon, 2-Nitro-4-Azidophenylsulfenyl-
CAS No.	76359-36-9
Molecular Formula	C165H248N50O49S2 (for Glucagon(1-29) modified)
Molecular Weight	~3483.2 g/mol (for modified peptide)
Synonyms	2-Nitro-4-azidophenylsulfenyl glucagon; NAPS-Glucagon; Glucagon modified with 2-nitro-4-azidophenylsulfenyl group; Photoactivatable glucagon derivative; Glucagon aryl azide derivative; Glucagon photoreactive crosslinker; 4-Azido-2-nitrophenylsulfenyl glucagon
EINECS	Contact for details

Quality Control

Our Glucagon, 2-Nitro-4-Azidophenylsulfenyl- is produced under controlled conditions to ensure high purity and batch-to-batch consistency suitable for sensitive research applications. Each lot undergoes rigorous analytical testing, including HPLC for purity and MS for identity confirmation. A comprehensive Certificate of Analysis (COA) detailing purity, peptide content, and functional validation is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, consider desiccation and storage under an inert atmosphere. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Off-white to light yellow lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Water Content (KF)	≤ 5.0%
Solubility	Soluble in DMSO, DMF; slightly soluble in aqueous buffers
Functional Activity	Retains receptor binding capability (tested by competitive binding assay)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.