Description

24,25,26-Trihydroxyvitamin D3 is a biologically active metabolite of vitamin D3, representing a key intermediate in the calcitriol catabolic pathway. This high-purity compound is critical for research and development in endocrinology and metabolic bone disease studies. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and manufacturers of advanced reference standards and diagnostic kits.

Application

• Pharmaceutical Research & Development: As a key metabolite for studying vitamin D metabolism, receptor interactions, and the regulation of calcium and phosphate homeostasis.
• Biochemical Reference Standard: Used for the calibration of analytical instruments (HPLC, LC-MS) and as a certified reference material in quantitative assays.
• Metabolic Pathway Studies: Investigation of the 24-hydroxylation pathway and the inactivation mechanism of 1,25-dihydroxyvitamin D3 (calcitriol).
• In-Vitro Diagnostic (IVD) Manufacturing: A critical raw material in the production of immunoassay kits for measuring vitamin D metabolite levels in clinical samples.
• Academic & Clinical Research: Fundamental research into bone biology, renal function, and diseases related to vitamin D dysregulation.

Basic Information

Product Name	24,25,26-Trihydroxyvitamin D3
CAS No.	76355-23-2
Molecular Formula	C₂₇H₄₄O₅
Molecular Weight	448.64 g/mol
Synonyms	24R,25,26-Trihydroxycholecalciferol; (24R)-24,25,26-Trihydroxyvitamin D3; 24,25,26-Trihydroxycolecalciferol; 24,25,26-Trihydroxycholecalciferol; Vitamin D3 metabolite 24,25,26-triol; 1α,25-Dihydroxyvitamin D3-24,25,26-triol catabolite
EINECS	Contact for details

Quality Control

Our 24,25,26-Trihydroxyvitamin D3 is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing including HPLC for purity and identity confirmation by NMR and mass spectrometry. We provide a comprehensive Certificate of Analysis (COA) with each shipment, detailing all specified parameters to ensure compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the container to reach room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with reference structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.