Description

4-Amino-5-Bromo-2-Methoxy-n-[8-[[3-(Trifluoromethyl)Phenyl]Methyl]-8-A Zabicyclo[3.2.1]Oct-3-Yl]Benzamide is a sophisticated, high-purity organic compound featuring a complex bridged bicyclic structure, making it a valuable advanced pharmaceutical intermediate. Its unique molecular architecture, incorporating bromo, amino, methoxy, and trifluoromethylphenyl groups, is specifically engineered for targeted synthesis. This compound is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and receptor-targeted therapies.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the multi-step synthesis of complex drug candidates and novel chemical entities (NCEs).
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for discovering new therapeutic agents.
• Preclinical Development: Employed in the production of compounds for pharmacological profiling, toxicology studies, and formulation development.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and process development for client projects.
• Academic Research: Utilized in university and institutional labs for studying synthetic methodologies and heterocyclic chemistry.
• Reference Standard: Can be supplied as a high-purity analytical standard for method development and quality control in API production.

Basic Information

Product Name	4-Amino-5-Bromo-2-Methoxy-n-[8-[[3-(Trifluoromethyl)Phenyl]Methyl]-8-A Zabicyclo[3.2.1]Oct-3-Yl]Benzamide
CAS No.	76351-90-1
Molecular Formula	C25H27BrF3N3O2
Molecular Weight	538.40 g/mol
Synonyms	4-Amino-5-bromo-2-methoxy-N-[8-[[3-(trifluoromethyl)phenyl]methyl]-8-azabicyclo[3.2.1]oct-3-yl]benzamide; 76351-90-1; 8-[[3-(Trifluoromethyl)benzyl]-8-azabicyclo[3.2.1]oct-3-yl 4-Amino-5-bromo-2-methoxybenzamide; Benzamide, 4-amino-5-bromo-2-methoxy-N-[8-[[3-(trifluoromethyl)phenyl]methyl]-8-azabicyclo[3.2.1]oct-3-yl]-
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency and high purity. Quality is verified through a comprehensive suite of analytical techniques including HPLC, NMR, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting identity, purity, and impurity profiles. We support development and commercial projects with specifications that can meet GMP-grade requirements upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Single Maximum Impurity	≤ 1.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.