Description

n-(1-Pyrenesulfonyl)Dipalmitoyl-L-α-Phosphatidylethanolamine is a high-purity, fluorescently labeled phospholipid derivative, essential for advanced biophysical and biochemical research. Its core value lies in the pyrene fluorophore, which enables sensitive detection and analysis of membrane dynamics, lipid-protein interactions, and vesicle trafficking. This compound is critically needed by researchers and developers in pharmaceutical discovery, lipidomics, and advanced materials science for creating sophisticated probes and model membrane systems.

Application

• Fluorescent Membrane Probe: Used to study lipid bilayer properties, membrane fluidity, fusion, and lipid domain formation via pyrene excimer/monomer fluorescence.
• Lipid-Protein Interaction Studies: Acts as a tagged substrate or competitor to investigate binding kinetics and specificity of phospholipid-binding proteins and enzymes.
• Liposome & Nanoparticle Tracking: Incorporated into liposomal formulations or lipid nanoparticles (LNPs) for visualizing cellular uptake, biodistribution, and intracellular fate in drug delivery research.
• Cell Biology Assays: Serves as a tracer for monitoring endocytosis, exocytosis, and intracellular vesicle transport pathways.
• Biophysical Sensor Development: Utilized in constructing fluorescence-based sensors for detecting membrane curvature, charge, or enzymatic activity.
• Model Membrane Systems: A key component in creating defined, traceable artificial membranes for high-throughput screening and diagnostic platform development.

Basic Information

Product Name	n-(1-Pyrenesulfonyl)Dipalmitoyl-L-α-Phosphatidylethanolamine
CAS No.	76341-59-8
Molecular Formula	C67H104NO11PS
Molecular Weight	1162.58 g/mol
Synonyms	1,2-Dipalmitoyl-sn-glycero-3-phosphoethanolamine-N-(1-pyrenesulfonyl); Pyrene-PE; Pyrenesulfonyl Phosphatidylethanolamine; N-(1-Pyrenesulfonyl)-DPPE; DPPE-Pyrene; Fluorescent DPPE; Pyrene-labeled PE; Pyrene sulfonamide PE
EINECS	Contact for details

Quality Control

Our n-(1-Pyrenesulfonyl)Dipalmitoyl-L-α-Phosphatidylethanolamine is produced under strict quality management protocols to ensure batch-to-batch consistency and high performance in sensitive applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity, mass spectrometry for identity confirmation, and fluorescence spectroscopy to verify spectral properties. A detailed Certificate of Analysis (COA) documenting all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is both light-sensitive and hygroscopic. For long-term stability, store under an inert atmosphere (argon or nitrogen) and allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Yellow to orange solid or film
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95% (Area %)
Extinction Coefficient (ε)	~40,000 M-1cm-1 (in methanol, ~345 nm)
Fluorescence Emission	Peak ~376 nm & ~397 nm (monomer)
Solubility	Chloroform, Methanol, DMSO
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.