Description

1,25-Dihydroxy-24-Oxo-Vitamin D3 is a biologically active metabolite and synthetic analog of vitamin D, representing a key compound in the study of calcitriol pathways and receptor interactions. This high-purity reference standard is critical for pharmaceutical research and development, particularly in exploring novel therapeutic agents for bone metabolism disorders, psoriasis, and certain cancers. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and advanced life science sectors requiring precise and reliable bioactive molecules for assay development, metabolic studies, and drug discovery programs.

Application

• Pharmaceutical Reference Standard: Serves as a primary standard for the quality control and assay validation of vitamin D analogs and related pharmaceutical products.
• Biochemical Research: Used in vitro and in vivo studies to investigate the non-classical actions of vitamin D, including cell differentiation, proliferation, and immunomodulation.
• Drug Discovery & Development: A key intermediate or active pharmaceutical ingredient (API) in the synthesis and development of next-generation vitamin D receptor (VDR) agonists and antagonists.
• Metabolic Pathway Analysis: Employed in metabolic studies to elucidate the catabolic pathways of 1,25-dihydroxyvitamin D3 and the role of the 24-oxo moiety.
• Diagnostic Kit Manufacturing: Utilized in the production of calibration standards and controls for clinical diagnostic assays measuring vitamin D metabolites.

Basic Information

Product Name	1,25-Dihydroxy-24-Oxo-Vitamin D3
CAS No.	76338-50-6
Molecular Formula	C₂₇H₄₀O₅
Molecular Weight	444.60 g/mol
Synonyms	24-Oxo-1,25-dihydroxyvitamin D3; 1,25-Dihydroxy-24-oxocholecalciferol; 24-Oxocalcitriol; 1α,25-Dihydroxy-24-oxovitamin D3; (5Z,7E)-9,10-Secocholesta-5,7,10(19)-triene-1α,3β,25-triol-24-one; 24-Oxo-1α,25-dihydroxyvitamin D₃
EINECS	Contact for details

Quality Control

Our 1,25-Dihydroxy-24-Oxo-Vitamin D3 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, MS), to ensure it meets the stringent requirements for research and development use. Certificates of Analysis (COA) detailing batch-specific results are provided with every shipment. We support compliance with relevant pharmacopeial standards for reference materials.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation and degradation. For long-term storage, keep desiccated to maintain stability. Allow the sealed container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Solubility	Soluble in ethanol, DMSO; sparingly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.