Description

Carprofenacyl-Glucuronide CAS NO 76319-13-6 is a key metabolite of the non-steroidal anti-inflammatory drug (NSAID) carprofen, formed via glucuronidation. This compound is of significant importance in pharmaceutical research and development, particularly for studying drug metabolism, pharmacokinetics, and safety profiles. It is primarily needed by analytical laboratories, contract research organizations (CROs), and pharmaceutical companies engaged in bioanalytical method development, metabolite identification, and regulatory toxicology studies.

Application

• Reference Standard for Bioanalysis: Used as a certified reference material (CRM) for the quantitative and qualitative analysis of carprofen and its metabolites in biological matrices (plasma, urine) via LC-MS/MS or HPLC.
• Metabolite Profiling & Identification: Essential for in vitro and in vivo ADME (Absorption, Distribution, Metabolism, Excretion) studies to map the metabolic pathway of carprofen.
• Pharmacokinetic (PK) Studies: Serves as a critical calibrant for determining the concentration-time profile of carprofen's major metabolite to understand drug clearance and half-life.
• Toxicology & Safety Assessment: Employed in investigative toxicology to assess the potential role of metabolites in drug-induced liver injury or other adverse effects.
• Veterinary Pharmaceutical Research: Supports R&D for veterinary medicines, given carprofen's primary use in dogs, ensuring comprehensive safety and efficacy data for regulatory submissions.
• Method Development & Validation: Acts as a primary standard for developing, validating, and transferring robust analytical methods in compliance with GLP (Good Laboratory Practice) and ICH guidelines.

Basic Information

Product Name	Carprofenacyl-Glucuronide
CAS No.	76319-13-6
Molecular Formula	C23H24ClNO9
Molecular Weight	493.89 g/mol
Synonyms	Carprofen Glucuronide; Carprofen Acyl Glucuronide; 2-[(2-Carbazol-4-yloxy)phenyl]propionic acid 1-β-O-acyl glucuronide; 6,11-Dihydro-11-oxodibenz[b,e]oxepin-2-acetic acid glucuronide; (RS)-6-Chloro-α-methyl-9H-carbazole-2-acetic acid β-1-O-acyl glucuronide; Carprofen metabolite M3; Carprofen β-D-Glucopyranosiduronic Acid
EINECS	Contact for details

Quality Control

Our Carprofenacyl-Glucuronide is manufactured under strict quality control protocols suitable for research and analytical applications. Each batch is characterized using advanced spectroscopic and chromatographic techniques to ensure high purity and structural identity. We provide comprehensive Certificates of Analysis (COA) with batch-specific data, including purity by HPLC, confirmation by NMR and MS, and impurity profiles. Our quality system supports work in GLP-compliant environments.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.