Description

n-Benzyl-n-(tert-Butoxycarbonyl)Glycine is a protected amino acid derivative, specifically a glycine molecule with orthogonal protecting groups on the nitrogen atom. This compound is a crucial building block in solid-phase peptide synthesis (SPPS), enabling the controlled and sequential assembly of complex peptides. It is primarily utilized by pharmaceutical R&D departments, biotechnology companies, and fine chemical manufacturers engaged in the development of peptide-based therapeutics, diagnostics, and research reagents.

Application

• Peptide Synthesis Building Block: A key intermediate for the controlled incorporation of glycine residues during Fmoc/tBu solid-phase peptide synthesis (SPPS).
• Pharmaceutical Intermediate: Used in the research and development of novel peptide drugs, including hormones, enzyme inhibitors, and antimicrobial peptides.
• Bioconjugation Reagent: Serves as a linker or spacer molecule for attaching peptides to other biomolecules, surfaces, or carrier proteins.
• Combinatorial Chemistry: Employed in the generation of peptide libraries for high-throughput screening in drug discovery programs.
• Academic & Industrial Research: Essential for biochemical and pharmacological studies requiring custom-designed peptides.
• Fine Chemical Synthesis: Acts as a versatile chiral synthon for the preparation of more complex, non-peptide molecules in organic chemistry.

Basic Information

Product Name	n-Benzyl-n-(tert-Butoxycarbonyl)Glycine
CAS No.	76315-01-0
Molecular Formula	C14H19NO4
Molecular Weight	265.31 g/mol
Synonyms	N-Boc-N-benzylglycine; Boc-N-Benzyl-glycine; (tert-Butoxycarbonyl)(benzyl)aminoacetic Acid; N-(tert-Butoxycarbonyl)-N-benzylglycine; N-Benzyl-N-Boc-glycine; 2-[(Benzyl)(tert-butoxycarbonyl)amino]acetic Acid; Bn-Boc-Gly-OH; Boc-Gly(Bn)-OH
EINECS	Contact for details

Quality Control

Our n-Benzyl-n-(tert-Butoxycarbonyl)Glycine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for pharmaceutical research and peptide synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be kept under inert atmosphere for long-term storage to maintain optimal purity and stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.