Description

Rac-7-Hydroxy Propranolol (Hydrochloride) is a key metabolite and synthetic intermediate of the widely used β-blocker, propranolol. This compound is of significant importance for pharmaceutical research and development, particularly in metabolic studies, pharmacokinetic profiling, and the synthesis of reference standards. It is primarily utilized by research institutions, pharmaceutical companies, and analytical laboratories engaged in drug metabolism, impurity characterization, and advanced organic synthesis.

Application

• Pharmaceutical Reference Standard: Serves as a critical certified reference material (CRM) for the identification and quantification of propranolol metabolites in biological matrices and pharmaceutical formulations.
• Metabolite Research: Essential for in vitro and in vivo studies investigating the metabolic pathways, bioavailability, and clearance mechanisms of propranolol.
• Impurity Profiling: Used as a known impurity standard in the quality control and stability testing of propranolol active pharmaceutical ingredients (APIs) and finished dosage forms to ensure compliance with ICH guidelines.
• Organic Synthesis Intermediate: Acts as a valuable chiral building block or precursor in the synthesis of more complex molecules or labeled analogs for tracer studies.
• Analytical Method Development: Employed for the development and validation of analytical methods such as HPLC, LC-MS, and GC-MS for propranolol and its related substances.

Basic Information

Product Name	Rac-7-Hydroxy Propranolol (Hydrochloride)
CAS No.	76275-67-7
Molecular Formula	C₁₆H₂₂ClNO₃
Molecular Weight	311.80 g/mol
Synonyms	7-Hydroxypropranolol Hydrochloride; (±)-7-Hydroxypropranolol HCl; 1-[(1-Methylethyl)amino]-3-(naphthalen-1-yloxy)propan-2-ol, 7-Hydroxy-, Hydrochloride; Propranolol Metabolite 7-Hydroxy HCl; 1-(Isopropylamino)-3-(7-hydroxy-1-naphthyloxy)-2-propanol Hydrochloride; 4-[2-Hydroxy-3-[(1-methylethyl)amino]propoxy]-1-naphthalenol Hydrochloride; Rac-7-OH-Propranolol HCl
EINECS	Contact for details

Quality Control

Our Rac-7-Hydroxy Propranolol (Hydrochloride) is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure high purity and batch-to-batch consistency suitable for research applications. Quality is verified against in-house specifications using advanced techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.