Description

Fmoc-Met(O)-Oh CAS NO 76265-70-8 is a protected amino acid derivative where the methionine side chain is in its sulfoxide form and the α-amino group is protected by a 9-fluorenylmethoxycarbonyl (Fmoc) group. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the controlled incorporation of methionine sulfoxide into peptide chains. It is primarily utilized by research institutions and pharmaceutical companies engaged in peptide drug discovery, proteomics research, and the synthesis of complex biomolecules.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the Fmoc-strategy synthesis of peptides containing methionine sulfoxide residues.
• Peptide Drug Development: Used in the research and production of therapeutic peptides where methionine oxidation is a factor in activity or stability studies.
• Bioconjugation and Protein Engineering: Serves as a modified amino acid precursor for site-specific incorporation into engineered proteins.
• Proteomics and Biochemical Research: Employed in the study of oxidative post-translational modifications and their biological roles.
• Reference Standard: Acts as a high-purity analytical standard for chromatography and mass spectrometry in peptide analysis.
• Combinatorial Chemistry: Used in libraries for drug screening to explore structure-activity relationships involving oxidized methionine.

Basic Information

Product Name	Fmoc-Met(O)-Oh
CAS No.	76265-70-8
Molecular Formula	C₂₀H₂₁NO₅S
Molecular Weight	387.45 g/mol
Synonyms	Fmoc-Met(O)-OH; Fmoc-L-methionine S-oxide; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-methionine S-oxide; (2S)-2-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-4-(methylsulfinyl)butanoic acid; Fmoc-L-Methionine Sulfoxide; N-Fmoc-L-methionine sulfoxide; Fmoc-Met(O2)-OH; Fmoc-Met(O)-OH, 98+%
EINECS	Contact for details

Quality Control

Our Fmoc-Met(O)-Oh is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis, and identity confirmation, to ensure it meets the high standards required for peptide synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	-15.0° to -20.0° (c=1 in DMF)
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.