Description

(4-Methylumbelliferyl)-n-Acetyl-α-D-Neuraminic Acid Sodium Salt is a high-purity fluorogenic substrate specifically designed for the sensitive detection and quantification of neuraminidase (sialidase) enzyme activity. This compound is critical for research and diagnostic applications where precise enzymatic measurement is required. It is primarily utilized by biotechnology firms, pharmaceutical research laboratories, and diagnostic kit manufacturers focused on virology, glycobiology, and bacterial pathogenesis studies.

Application

• Neuraminidase/Sialidase Activity Assays: The primary application is as a fluorogenic substrate in continuous or endpoint assays to measure neuraminidase activity from viral, bacterial, or mammalian sources.
• Influenza Virus Research: Essential for screening and evaluating potential antiviral compounds, particularly neuraminidase inhibitors, in drug discovery programs targeting influenza.
• Diagnostic Kit Manufacturing: Used as a key reagent in the production of commercial diagnostic kits for detecting pathogens like influenza viruses that express neuraminidase.
• Glycobiology Studies: Employed in research to study sialic acid metabolism, cell surface glycan remodeling, and the role of sialidases in cellular signaling and disease.
• Bacterial Pathogenesis Research: Applied in studies of bacterial neuraminidases, which are virulence factors for pathogens such as *Clostridium perfringens* and *Vibrio cholerae*.
• High-Throughput Screening (HTS): Ideal for automated HTS platforms in pharmaceutical labs due to its fluorogenic properties, enabling rapid and sensitive readouts.
• Enzyme Kinetics & Characterization: Used to determine kinetic parameters (Km, Vmax) and pH optima for purified neuraminidase enzymes.

Basic Information

Product Name	(4-Methylumbelliferyl)-n-Acetyl-α-D-Neuraminic Acid Sodium Salt
CAS No.	76204-02-9
Molecular Formula	C₂₀H₂₄NNaO₁₂
Molecular Weight	517.40 g/mol
Synonyms	4-MU-NANA Sodium Salt; 4-Methylumbelliferyl N-Acetyl-α-D-neuraminic Acid Sodium Salt; 4-MU-α-D-Neu5Ac Sodium Salt; MUNANA Sodium Salt; Fluorogenic Neuraminidase Substrate; 4-Methylumbelliferyl-α-D-N-acetylneuraminate Sodium Salt; (4-MU)-α-Neu5Ac Na Salt; 2-O-(4-Methylumbelliferyl)-α-D-N-acetylneuraminic Acid Sodium Salt
EINECS	Contact for details

Quality Control

Every batch of our (4-Methylumbelliferyl)-n-Acetyl-α-D-Neuraminic Acid Sodium Salt is manufactured and tested under strict quality management systems to ensure the high purity and consistency required for sensitive research and diagnostic applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as HPLC purity, identity confirmation (NMR, MS), and specific activity. Our quality commitment aligns with standards relevant to research-grade biochemical reagents.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant and under an inert atmosphere to maintain stability and prevent hydrolysis. Allow the product to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Activity	Contact for details
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.