Description

Di-tert-Butyl(Trimethylsilylmethyl)Phosphine is a highly specialized organophosphorus compound, valued for its role as a versatile ligand and reagent in advanced synthetic chemistry. Its sterically hindered and silyl-protected structure makes it particularly effective in facilitating challenging cross-coupling reactions and stabilizing low-coordinate metal centers. This chemical is essential for R&D and production in pharmaceutical development, materials science, and fine chemical synthesis, where precise molecular control is paramount.

Application

• Ligand in Homogeneous Catalysis: Used in palladium- and nickel-catalyzed cross-coupling reactions (e.g., Suzuki, Negishi) for constructing complex organic molecules.
• Pharmaceutical Intermediate Synthesis: A key building block in the development of active pharmaceutical ingredients (APIs), especially for creating novel carbon-phosphorus bonds.
• Polymerization Catalyst Component: Serves as a co-catalyst or ligand in the synthesis of specialized polymers and advanced materials.
• Organometallic Chemistry Research: Employed in academic and industrial R&D to synthesize and stabilize novel metal complexes and study reaction mechanisms.
• Agrochemical Synthesis: Used in the research and production of advanced crop protection agents and plant growth regulators.
• Fine Chemical Manufacturing: Applied in the multi-step synthesis of high-value, complex specialty chemicals.

Basic Information

Item	Details
Product Name	Di-tert-Butyl(Trimethylsilylmethyl)Phosphine
CAS No.	76181-99-2
Molecular Formula	C12H29PSi
Molecular Weight	232.41 g/mol
Synonyms	Di-tert-butyl(trimethylsilylmethyl)phosphane; (Trimethylsilyl)methyl-di-tert-butylphosphine; Di-tert-butyl(trimethylsilylmethyl)phosphorus; t-Bu2PCH2SiMe3; DTBP; Di-t-butyl(trimethylsilylmethyl)phosphine; Phosphine, [(trimethylsilyl)methyl]bis(1,1-dimethylethyl)-
EINECS	Contact for details

Quality Control

Every batch of Di-tert-Butyl(Trimethylsilylmethyl)Phosphine is produced and tested under stringent quality management protocols to ensure consistency and purity for critical applications. Our standard quality assurance includes comprehensive analysis via NMR, GC, and HPLC to verify identity and assay. Certificates of Analysis (COA) documenting all relevant specifications are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C in a cool, dry, well-ventilated area. Keep away from strong oxidizers and moisture. Allow the container to reach ambient temperature before opening to minimize condensation and exposure.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (NMR)	Conforms to structure
Assay (GC/HPLC)	≥ 95.0%
Purity (NMR)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.