Description

Boc-Arg(Z)2-Osu CAS NO 76052-29-4 is a protected amino acid derivative, specifically an N-Boc and N-Cbz (Z) protected arginine active ester. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the controlled and efficient incorporation of arginine into peptide chains. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors who require high-purity intermediates for the development of therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key protected arginine derivative for the automated synthesis of complex peptides.
• Pharmaceutical Intermediates: For the research and production of peptide-based active pharmaceutical ingredients (APIs) and drug candidates.
• Bioconjugation: Used in the chemical modification of proteins and other biomolecules to introduce arginine residues or functional handles.
• Biochemical Research: As a reagent for studying enzyme-substrate interactions, protein-protein binding, and signal transduction pathways.
• Antimicrobial Peptide Development: For constructing peptides with cationic properties, which are crucial for many antimicrobial and cell-penetrating peptides.
• Custom Peptide Services: A fundamental raw material for CROs and CDMOs offering bespoke peptide manufacturing.

Basic Information

Product Name	Boc-Arg(Z)2-Osu
CAS No.	76052-29-4
Molecular Formula	C26H40N6O8
Molecular Weight	564.64 g/mol
Synonyms	Nα-Boc-Nω,Nω'-bis(Cbz)-L-arginine N-succinimidyl ester; Nα-Boc-Nω,Nω'-bis(benzyloxycarbonyl)-L-arginine succinimidyl ester; Boc-Arg(Z)2-OSu; Boc-L-Arg(Z)2-OSu; Nα-(tert-Butoxycarbonyl)-Nω,Nω'-bis(benzyloxycarbonyl)-L-arginine N-hydroxysuccinimide ester; Nα-Boc-Nω,Nω'-dibenzyloxycarbonyl-L-arginine succinimidyl ester; (2,5-Dioxopyrrolidin-1-yl) (2S)-5-[(benzyloxycarbonyl)amino]-2-{[(2-methylpropan-2-yl)oxycarbonyl]amino}-Nω-(benzyloxycarbonyl)pentanimidate
EINECS	Contact for details

Quality Control

Our Boc-Arg(Z)2-Osu is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and chiral analysis to ensure enantiomeric integrity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports applications requiring GMP-grade intermediates and research materials for regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.