Description

Fluphenazine-N(4')-Oxide is a key pharmaceutical intermediate and a metabolite of the antipsychotic agent fluphenazine. This compound is of significant importance for research and development in neuropharmacology and analytical chemistry. It is primarily utilized by pharmaceutical manufacturers and research institutions for the synthesis of active pharmaceutical ingredients (APIs), method development, and as a reference standard in quality control laboratories.

Application

• Pharmaceutical Intermediate: Critical for the synthesis and development of fluphenazine-based antipsychotic medications.
• Reference Standard: Used as a high-purity certified standard for analytical method validation, quality control, and regulatory compliance testing (e.g., HPLC, GC-MS).
• Metabolite Studies: Essential for pharmacokinetic and metabolic pathway research related to fluphenazine in both preclinical and clinical settings.
• Impurity Profiling: Employed to identify, quantify, and control process-related impurities and degradation products in fluphenazine drug substances and finished products.
• Research & Development: Serves as a building block in medicinal chemistry for creating novel analogs and studying structure-activity relationships (SAR).

Basic Information

Product Name	Fluphenazine-N(4')-Oxide
CAS No.	76005-59-9
Molecular Formula	C₂₂H₂₆F₃N₃OS
Molecular Weight	437.52 g/mol
Synonyms	Fluphenazine N-Oxide; Fluphenazine Sulfoxide; 2-[4-[3-[2-(Trifluoromethyl)-10H-phenothiazin-10-yl]propyl]-1-piperazinyl]ethanol S-Oxide; 10-[3-[4-(2-Hydroxyethyl)piperazin-1-yl]propyl]-2-(trifluoromethyl)phenothiazine 5-Oxide; Fluphenazine Sulfoxide; Prolixin N-Oxide; Flufenazin-N-oxid; Fluphenazinum
EINECS	Contact for details

Quality Control

Our Fluphenazine-N(4')-Oxide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical research and development. A detailed Certificate of Analysis (COA) providing results for assay, related substances, residual solvents, and other critical parameters is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single unknown impurity ≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.