Description

Cephradine Monohydrate CAS NO 75975-70-1 is a first-generation cephalosporin antibiotic in its monohydrate crystalline form. This compound is valued for its broad-spectrum bactericidal activity against a range of Gram-positive and some Gram-negative bacteria. It is a critical active pharmaceutical ingredient (API) primarily required by pharmaceutical manufacturers for the formulation of oral dosage forms such as capsules and tablets.

Application

• Primary use as an Active Pharmaceutical Ingredient (API) in the manufacture of oral antibiotic formulations.
• Formulation of generic cephalosporin antibiotic capsules and tablets for human use.
• Used in veterinary pharmaceutical applications for treating bacterial infections in animals.
• Essential raw material for clinical research and development of antibacterial therapies.
• Reference standard material for quality control and analytical testing in pharmaceutical laboratories.
• Potential use in the synthesis of more complex antibiotic derivatives or prodrugs.

Basic Information

Product Name	Cephradine Monohydrate
CAS No.	75975-70-1
Molecular Formula	C16H19N3O4S • H2O
Molecular Weight	349.41 g/mol
Synonyms	Cephradine Hydrate; 7-[(2R)-2-Amino-2-(1,4-cyclohexadien-1-yl)acetamido]-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid Monohydrate; SQ-11436; Cefradine Monohydrate; Velosef; Anspor; Sefril; Cefradin Monohydrate
EINECS	Contact for details

Quality Control

Our Cephradine Monohydrate is manufactured and tested to meet stringent pharmaceutical-grade standards, including relevant pharmacopoeial monographs (e.g., USP, EP, BP). Every batch undergoes comprehensive analytical testing to ensure identity, purity, potency, and the absence of critical impurities. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a low-humidity environment to prevent degradation and clumping.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to standard
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	4.0% - 6.0%
pH (5% aqueous suspension)	3.5 - 6.0
Related Substances (HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	≤ 20 ppm
Microbial Enumeration	Complies with EP/USP for non-sterile substances

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.