Description

n-(2-Bromoethyl)-2,2,2-trifluoroacetamide is a specialized fluorinated building block of significant interest in advanced organic synthesis. This compound matters for its bifunctional reactivity, featuring both a bromoethyl handle for nucleophilic substitution and a trifluoroacetamide group that can serve as a protected amine or a source of fluorine atoms. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing complex molecules, particularly in the development of new active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, especially those incorporating fluorine for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides where the trifluoromethyl group is a critical pharmacophore.
• Fluorinated Material Precursor: Serves as a monomer or intermediate in the development of specialty polymers and materials with unique surface properties.
• Cross-coupling Reactions: The bromoethyl moiety acts as an electrophile in various palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) to form carbon-carbon bonds.
• Ligand and Catalyst Development: Useful for synthesizing novel fluorinated ligands for catalysis or as a scaffold in medicinal chemistry for structure-activity relationship (SAR) studies.
• Protecting Group Strategy: The trifluoroacetamide group can act as a protecting group for amines in multi-step synthetic sequences.

Basic Information

Product Name	n-(2-Bromoethyl)-2,2,2-trifluoroacetamide
CAS No.	75915-38-7
Molecular Formula	C4H5BrF3NO
Molecular Weight	220.0 g/mol
Synonyms	2-Bromo-N-(2,2,2-trifluoroacetyl)ethanamine; 2,2,2-Trifluoro-N-(2-bromoethyl)acetamide; N-(2-Bromoethyl)trifluoroacetamide; 2-Bromoethyltrifluoroacetamide; 1-Bromo-2-(trifluoroacetamido)ethane; Ethanamine, 2-bromo-N-(2,2,2-trifluoroacetyl)-; TFA-Bromoethylamine
EINECS	Contact for details

Quality Control

Our n-(2-Bromoethyl)-2,2,2-trifluoroacetamide is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity for research and scale-up applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support compliance with relevant frameworks for chemical manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and away from direct light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.