Description

n-Desisobutyl-n-Propyl Rifabutin is a key chemical intermediate and derivative of the antibiotic rifabutin. This compound is critical for pharmaceutical research and development, particularly in the synthesis and structural modification of rifamycin-class antibiotics to enhance efficacy or study metabolic pathways. It is primarily required by pharmaceutical R&D laboratories, fine chemical manufacturers, and academic institutions engaged in antimicrobial drug discovery and advanced organic synthesis.

Application

• Pharmaceutical Intermediate: Serves as a crucial building block in the synthesis of novel rifabutin analogs and related antimicrobial agents.
• Research & Development: Used in metabolic and pharmacokinetic studies to understand the degradation pathways of rifabutin.
• Reference Standard: Acts as a certified reference material (CRM) for analytical method development and quality control testing in pharmaceutical manufacturing.
• Process Chemistry: Employed in scaling up and optimizing synthetic routes for rifamycin-based active pharmaceutical ingredients (APIs).
• Academic Research: Utilized in university and institutional labs for studying structure-activity relationships (SAR) within the ansamycin antibiotic class.

Basic Information

Product Name	n-Desisobutyl-n-Propyl Rifabutin
CAS No.	75903-10-5
Molecular Formula	C42H58N4O11
Molecular Weight	794.93 g/mol
Synonyms	Rifabutin Desisobutyl Despropyl Derivative; 25-Desisobutyl-25-despropylrifabutin; LM 427 Desisobutyl Despropyl; Rifabutin Impurity; Ansamycin Derivative; Antibiotic LM 427 Analog; (12Z,14E,24E)-(2S,16S,17S,18R,19R,20S,21S,22R,23S)-21-Acetoxy-6,9,17,19-tetrahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-1,11-dioxo-1,2-dihydro-2,7-(epoxypentadeca[1,11,13]trienimino)naphtho[2,1-b]furan-5-yl acetate
EINECS	Contact for details

Quality Control

Our n-Desisobutyl-n-Propyl Rifabutin is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and stringent control of related substances. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to ensure traceability and compliance with your research or manufacturing standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	Orange to Red Powder
Identification (HPLC)	Conforms to Reference Standard
Identification (IR)	Conforms to Structure
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Individual Impurity ≤ 2.0%
Total Impurities	≤ 5.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.