Description

H-Dl-Phe-Otbu Hcl is a protected amino acid derivative of significant importance in synthetic organic and peptide chemistry. This compound serves as a versatile chiral building block, enabling the controlled synthesis of complex molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), peptide-based therapeutics, and fine chemical intermediates.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel Active Pharmaceutical Ingredients (APIs) and peptide-based drugs.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) as a protected phenylalanine derivative to incorporate the amino acid into peptide chains.
• Chemical Research: Serves as a crucial building block in academic and industrial research for constructing complex organic molecules and studying stereochemistry.
• Protecting Group Chemistry: The tert-butyl ester (OtBu) group provides a base-labile protecting strategy for carboxylic acids during multi-step syntheses.
• Bioconjugation & Labeling: Can be utilized in the preparation of modified peptides or conjugates for biochemical and diagnostic applications.
• Asymmetric Synthesis: Employed in the synthesis of non-natural amino acids and other chiral compounds requiring the phenylalanine moiety.

Basic Information

Product Name	H-Dl-Phe-Otbu Hcl
CAS No.	75898-47-4
Molecular Formula	C₁₄H₂₁NO₂·HCl
Molecular Weight	271.78 g/mol (Free base: 235.33 g/mol)
Synonyms	DL-Phenylalanine tert-butyl ester hydrochloride; (RS)-2-Amino-3-phenylpropanoic acid 1,1-dimethylethyl ester hydrochloride; H-DL-Phe-OtBu·HCl; tert-Butyl DL-phenylalaninate hydrochloride; DL-Phenylalanine, tert-butyl ester, hydrochloride; Phe(OtBu)-OH·HCl (racemic); N-Deprotected phenylalanine tert-butyl ester HCl salt; 2-Amino-3-phenylpropionic acid tert-butyl ester hydrochloride
EINECS	Contact for details

Quality Control

Our H-Dl-Phe-Otbu Hcl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation via IR and NMR spectroscopy. Certificates of Analysis (COA) detailing all specifications are provided to ensure traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	Racemic mixture (DL)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.