Description

17 α-Ethynylestradiol-17 β-D-Glucopyranosiduronic Acid is a key conjugated metabolite of the synthetic estrogen ethynylestradiol, formed via glucuronidation. This compound is of significant importance for pharmaceutical research and development, particularly in the study of drug metabolism, pharmacokinetics, and hormone-related biological pathways. It is primarily needed by research institutions, pharmaceutical companies, and analytical laboratories engaged in bioanalytical method development, metabolite identification, and toxicological studies.

Application

• Pharmaceutical Reference Standard: Serves as a certified reference material (CRM) for the quantitative and qualitative analysis of ethynylestradiol metabolites in biological matrices.
• Metabolite Research: Critical for in vitro and in vivo studies investigating the metabolic fate, clearance, and activity of synthetic estrogens.
• Bioanalytical Method Development: Used to validate and calibrate analytical methods such as LC-MS/MS and HPLC for precise detection in pharmacokinetic studies.
• Toxicology & Safety Assessment: Employed in studies assessing the long-term effects, excretion profiles, and potential bioaccumulation of hormonal compounds.
• Endocrinology Studies: A tool for researching the role of estrogen conjugates in hormonal regulation and their interactions with various biological systems.
• Quality Control in Manufacturing: Used as an impurity marker or a process control standard in the synthesis of steroidal APIs and related compounds.

Basic Information

Product Name	17 α-Ethynylestradiol-17 β-D-Glucopyranosiduronic Acid
CAS No.	75803-39-3
Molecular Formula	C26H34O8
Molecular Weight	474.55 g/mol
Synonyms	Ethynylestradiol Glucuronide; 17α-Ethynylestradiol 17-β-D-Glucuronide; EE2 17-Glucuronide; 17α-Ethynyl-1,3,5(10)-estratriene-3,17β-diol 17-β-D-Glucopyranosiduronic Acid; NSC 49110; Ethinyl Estradiol Glucuronide; EE2-G; 17α-Ethynylestradiol-17β-glucuronide
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for high-purity reference materials. Each batch is characterized using advanced analytical techniques to confirm identity, purity, and stability. Certificates of Analysis (COA) detailing lot-specific results from HPLC, NMR, and MS are available upon request, supporting your research and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be kept in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.