Description

Insulin, Tetrakis(3-Nitro-Tyr)- CAS NO 75788-76-0 is a chemically modified insulin derivative where four tyrosine residues have been nitrated. This compound is a critical research-grade biochemical tool, primarily used to study the structural and functional impacts of tyrosine nitration on protein activity and signaling pathways. It is essential for researchers in pharmaceutical development, biochemistry, and metabolic disease research who require high-purity, well-characterized probes to investigate oxidative stress, insulin signaling, and potential therapeutic targets.

Application

• Biochemical Research: A key reagent for studying the effects of protein nitration on insulin's structure, receptor binding affinity, and biological activity.
• Oxidative Stress Studies: Used as a model compound to investigate the role of reactive nitrogen species in metabolic disorders such as diabetes and insulin resistance.
• Pharmaceutical Development: Serves as a reference standard or tool compound in drug discovery programs targeting modified insulin pathways or nitrotyrosine-related pathologies.
• Analytical Method Development: Employed as a standard for developing and validating analytical techniques (e.g., HPLC, MS) for detecting and quantifying nitrated proteins.
• Antibody Production & Validation: Can be used as an antigen to generate and validate antibodies specific for nitrotyrosine epitopes within the insulin molecule.

Basic Information

Item	Details
Product Name	Insulin, Tetrakis(3-Nitro-Tyr)- CAS NO 75788-76-0
CAS No.	75788-76-0
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	3-Nitrotyrosine Insulin; Tetranitrotyrosyl Insulin; Nitrated Insulin; Insulin (3-NO2-Tyr)4; Peroxynitrite-Modified Insulin (model); Insulin, 3-Nitrotyrosine Derivative; Research Grade Nitro-Insulin
EINECS	Contact for details

Quality Control

Our Insulin, Tetrakis(3-Nitro-Tyr)- is produced and handled under stringent conditions to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot undergoes rigorous analytical characterization. Certificates of Analysis (COA) detailing purity, identification, and other critical parameters are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0 %
Biological Activity	Assessed by receptor binding assay (Data on COA)
Endotoxin Level	< 10 EU/mg (where specified)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.