Description

(7S)-7-[[(R)-5-Amino-5-Carboxy-1-Oxopentyl]Amino]-7-Methoxy-3-[[(5-Methyl-1,3,4-Thiadiazol-2-Yl)Thio]Methyl]Cepham-3-Ene-4-Carboxylic Acid is a key advanced pharmaceutical intermediate in the synthesis of modern cephalosporin antibiotics. This compound is critical for developing potent, broad-spectrum antibacterial agents with enhanced stability against β-lactamases. It is primarily utilized by pharmaceutical R&D departments and active pharmaceutical ingredient (API) manufacturers focused on next-generation anti-infective therapies.

Application

• Pharmaceutical Intermediate: Core building block for the synthesis of third and fourth-generation cephalosporin antibiotics.
• Antibacterial API Synthesis: Used in the production of active pharmaceutical ingredients targeting resistant bacterial strains.
• Medicinal Chemistry Research: Serves as a crucial scaffold for developing novel β-lactam compounds with improved pharmacological profiles.
• Process Development: Employed in scaling up and optimizing manufacturing routes for complex cephalosporin drugs.
• Reference Standard: Can be used as a high-purity analytical standard for quality control and regulatory submissions.

Basic Information

Product Name	(7S)-7-[[(R)-5-Amino-5-Carboxy-1-Oxopentyl]Amino]-7-Methoxy-3-[[(5-Methyl-1,3,4-Thiadiazol-2-Yl)Thio]Methyl]Cepham-3-Ene-4-Carboxylic Acid
CAS No.	75765-20-7
Molecular Formula	C20H26N6O7S2
Molecular Weight	526.59 g/mol
Synonyms	7-Methoxy-7-[(R)-2-(4-amino-4-carboxybutyramido)-2-(carboxymethyl)acetamido]-3-[(5-methyl-1,3,4-thiadiazol-2-ylthio)methyl]-3-cephem-4-carboxylic acid; Cefmenoxime Intermediate; Cefmenoxime Precursor; (6R,7S)-7-[[(2R)-2-Amino-2-carboxyethyl]thio]acetamido]-7-methoxy-3-[[(5-methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; SCE-1365 Intermediate; Antibiotic SCE-1365 derivative; 7β-[(R)-2-Amino-2-carboxyethylthioacetamido]-7α-methoxy-3-[(5-methyl-1,3,4-thiadiazol-2-ylthio)methyl]-1-dethia-1-oxacephem-4-carboxylic acid
EINECS	Contact for details

Quality Control

Our production of this advanced pharmaceutical intermediate adheres to strict cGMP (Current Good Manufacturing Practice) guidelines to ensure batch-to-batch consistency and traceability. Quality is verified through a comprehensive battery of analytical tests including HPLC for purity and related substances, chiral purity analysis, and elemental analysis. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single impurity	≤ 0.5%
Chiral Purity	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.