Description

Shiga Toxin CAS NO 75757-64-1 is a potent bacterial protein toxin primarily produced by *Shigella dysenteriae* and certain strains of *Escherichia coli* (STEC). This compound is of critical importance in biomedical research for studying the pathogenesis of hemorrhagic colitis and hemolytic uremic syndrome (HUS). It is an essential reagent for scientists and manufacturers in the fields of toxicology, vaccine development, diagnostic assay production, and targeted cancer therapy research.

Application

• Biomedical Research: Fundamental studies on toxin mechanisms, cellular uptake, and ribosome inactivation.
• Diagnostic Development: Key antigen for the production of immunoassays and rapid test kits to detect Shiga toxin-producing *E. coli* (STEC) infections.
• Vaccine Research: Used as an immunogen or target in the development of prophylactic and therapeutic vaccines against STEC.
• Cancer Therapy Studies: Investigation of Shiga toxin subunits for the creation of immunotoxins and targeted drug delivery systems.
• Toxicology & Safety Testing: Employed as a standard or control in cytotoxicity assays and food safety testing protocols.
• Antibody Production: Critical for generating and purifying specific monoclonal and polyclonal antibodies.
• Pharmaceutical Quality Control: Serves as a reference standard in relevant biopharmaceutical manufacturing processes.

Basic Information

Product Name	Shiga Toxin CAS NO 75757-64-1
CAS No.	75757-64-1
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Shiga Toxin; Shigella Toxin; Verotoxin; SLT (Shiga-like Toxin); Vero Cell Cytotoxin; STX; Stx; E. coli Shiga Toxin; Shigatoxin
EINECS	Contact for details

Quality Control

Our Shiga Toxin is produced and handled under stringent quality management systems. Each batch undergoes comprehensive analytical testing, including activity assays and purity assessments, to ensure consistency and reliability for critical research applications. Certificates of Analysis (COA) detailing specific purity, activity (e.g., CD50), and analytical methods (e.g., SDS-PAGE, HPLC) are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store frozen at -20°C or below. Avoid repeated freeze-thaw cycles. This material is hygroscopic (moisture-sensitive); ensure containers are sealed under inert conditions if specified. Handle in accordance with laboratory safety protocols for potent biological toxins.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder or solution
Identification (SDS-PAGE)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Biological Activity (Cytotoxicity Assay)	Specific activity provided on COA
Endotoxin Level (LAL)	< 1.0 EU/µg
Protein Content (BCA/Bradford)	Provided on COA
Solubility	Soluble in appropriate aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.