Description

2,4-Dichloro-1-Ethynylbenzene is a versatile halogenated aromatic alkyne building block of significant importance in advanced organic synthesis. Its unique structure, featuring both an ethynyl group and chlorine substituents, makes it a critical intermediate for constructing complex molecular architectures. This compound is primarily utilized by research and development chemists in the pharmaceutical and agrochemical industries for applications such as cross-coupling reactions and the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for creating complex aromatic and heterocyclic scaffolds via Sonogashira and other cross-coupling reactions.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, where the dichloro-ethynylbenzene core can be functionalized to modulate biological activity.
• Material Science Research: Serves as a monomer or precursor in the development of advanced polymers, liquid crystals, and organic electronic materials due to its rigid, conjugated structure.
• Chemical Synthesis Reagent: Employed in academic and industrial R&D labs as a versatile reagent for constructing carbon-carbon bonds and introducing the ethynyl functional group into target molecules.
• Ligand and Catalyst Development: Acts as a precursor for synthesizing specialized ligands used in homogeneous catalysis and metal-organic frameworks (MOFs).

Basic Information

Product Name	2,4-Dichloro-1-Ethynylbenzene
CAS No.	75717-77-0
Molecular Formula	C8H4Cl2
Molecular Weight	171.02 g/mol
Synonyms	1-Ethynyl-2,4-dichlorobenzene; 2,4-Dichlorophenylacetylene; 2,4-Dichloroethynylbenzene; (2,4-Dichlorophenyl)acetylene; 2,4-Dichloro-1-ethynyl-benzene; 2,4-Dichlorobenzene, ethynyl-
EINECS	Contact for details

Quality Control

Our 2,4-Dichloro-1-Ethynylbenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. The container should be kept tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.