Description

[R-[R*,R*-(Z)]]-α-[[(2-Amino-4-Thiazolyl)(Methoxyimino)Acetyl]Amino]-1,2,5,7-Tetrahydro-7-Oxo-4H-Furo[3,4-D][1,3]Thiazine-2-Acetic Acid is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is critical for the synthesis of third-generation cephalosporin antibiotics, offering a key building block for creating potent antimicrobial agents. It is essential for manufacturers in the pharmaceutical and fine chemical industries focused on developing and producing high-value active pharmaceutical ingredients (APIs).

Application

• Key Intermediate for Cephalosporin Antibiotics: Primarily used in the synthesis of advanced cephalosporin drugs, such as Cefotaxime and related third-generation antibiotics.
• Pharmaceutical Research & Development (R&D): Serves as a crucial starting material or intermediate in the discovery and process development of new antibacterial agents.
• Active Pharmaceutical Ingredient (API) Manufacturing: Integrated into the final chemical synthesis steps for producing bulk antibiotic APIs under Good Manufacturing Practice (GMP) conditions.
• Fine Chemical Synthesis: Utilized in specialized organic synthesis for constructing complex molecules with fused thiazine and furo rings.
• Reference Standard: Can be supplied as a high-purity analytical standard for quality control and regulatory testing in pharmaceutical laboratories.

Basic Information

Product Name	[R-[R*,R*-(Z)]]-α-[[(2-Amino-4-Thiazolyl)(Methoxyimino)Acetyl]Amino]-1,2,5,7-Tetrahydro-7-Oxo-4H-Furo[3,4-D][1,3]Thiazine-2-Acetic Acid
CAS No.	75679-12-8
Molecular Formula	C17H17N5O7S2
Molecular Weight	475.48 g/mol
Synonyms	(6R,7R)-7-[(Z)-2-(2-Amino-4-thiazolyl)-2-(methoxyimino)acetamido]-3-[(acetyloxy)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid (7ACA Derivative); Cefotaxime Intermediate; 7-ACA Side Chain Intermediate; 2-(2-Aminothiazol-4-yl)-2-(methoxyimino)acetic Acid Derivative; ATMA Derivative; 7β-[2-(2-Aminothiazol-4-yl)-2-(methoxyimino)acetamido]cephalosporanic Acid Derivative; Furo[3,4-d][1,3]thiazine-2-acetic Acid Derivative
EINECS	Contact for details

Quality Control

Our [R-[R*,R*-(Z)]]-α-[[(2-Amino-4-Thiazolyl)(Methoxyimino)Acetyl]Amino]-1,2,5,7-Tetrahydro-7-Oxo-4H-Furo[3,4-D][1,3]Thiazine-2-Acetic Acid is manufactured under strict quality systems. We provide material that meets exacting standards for pharmaceutical intermediate applications, with purity typically exceeding 98.0% (by HPLC). Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. Our quality commitment aligns with ICH guidelines and supports our customers' needs for regulatory filings and GMP compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a dry environment and opened under conditions of low humidity to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.2%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.