Description

Ethyl 4,4,4-Trifluoro-2-Methoxy-3-Oxobutyrate is a high-value fluorinated building block and ester derivative, essential for introducing the trifluoromethyl group into complex molecular architectures. Its unique structure, combining a reactive β-ketoester with a trifluoromethyl substituent, makes it a versatile intermediate for synthesizing advanced pharmaceuticals and agrochemicals. This compound is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for creating novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of fluorinated active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and anti-inflammatory drug candidates.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides where the trifluoromethyl group enhances biological activity and environmental stability.
• Fluorinated Material Precursor: Serves as a monomer or intermediate for creating specialty polymers, coatings, and liquid crystals with enhanced chemical resistance and optical properties.
• Organic Synthesis Reagent: Employed in Michael additions, Claisen condensations, and other C-C bond-forming reactions to construct complex, fluorinated organic molecules.
• Research & Development: Critical material in medicinal chemistry and process chemistry labs for exploring new chemical entities and optimizing synthetic routes.
• Fine Chemical Production: Intermediate in the manufacture of other high-value fluorinated fine chemicals and specialty reagents.

Basic Information

Product Name	Ethyl 4,4,4-Trifluoro-2-Methoxy-3-Oxobutyrate
CAS No.	75631-71-9
Molecular Formula	C7H9F3O4
Molecular Weight	214.14 g/mol
Synonyms	Ethyl 4,4,4-Trifluoro-3-oxo-2-methoxybutyrate; 4,4,4-Trifluoro-2-methoxy-3-oxobutanoic Acid Ethyl Ester; Ethyl 4,4,4-Trifluoroacetoacetate 2-Methyl Ether; 3-Oxo-2-methoxy-4,4,4-trifluorobutanoic Acid Ethyl Ester; TFMOB Ethyl Ester; 2-Methoxy-4,4,4-trifluoro-3-oxobutanoic Acid Ethyl Ester; Ethyl (2-Methoxy-4,4,4-trifluoro-3-oxobutanoate)
EINECS	Contact for details

Quality Control

Our Ethyl 4,4,4-Trifluoro-2-Methoxy-3-Oxobutyrate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, impurity profiles, and physical characteristics. Our production adheres to cGMP principles where applicable, ensuring consistent quality and traceability for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed when not in use to minimize exposure to moisture and air.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Specific Rotation	Contact for details
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.