Description

Pentasarcosyl Angiotensin II is a synthetic, chemically modified peptide analog of the endogenous vasoconstrictor hormone Angiotensin II. This compound is engineered for enhanced stability and specific receptor interaction, making it a critical research tool in cardiovascular and endocrine studies. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies for investigating hypertension pathways, drug discovery, and biochemical assay development.

Application

• Biomedical Research: Used as a stable reference standard and probe in studies of the renin-angiotensin system (RAS) and blood pressure regulation.
• Drug Discovery & Development: Serves as a key pharmacological tool for screening and validating new antihypertensive drug candidates targeting angiotensin receptors.
• Biochemical Assays: Employed in receptor binding assays, enzyme activity studies, and cell-based signaling experiments to understand angiotensin II receptor (AT1/AT2) function.
• Peptide Chemistry Studies: Acts as a model compound for studying the effects of sarcosine (N-methylglycine) substitution on peptide stability, bioavailability, and biological activity.
• Diagnostic Development: Potential use in the calibration and development of diagnostic kits for measuring components of the renin-angiotensin pathway.

Basic Information

Product Name	Pentasarcosyl Angiotensin II
CAS No.	75582-96-6
Molecular Formula	C₅₀H₇₄N₁₄O₁₂
Molecular Weight	1047.2 g/mol
Synonyms	[Sar¹, Ile⁸]-Angiotensin II; Sar¹-Ile⁸-Angiotensin II; 1-Sarcosine-8-Isoleucine Angiotensin II; N-Methylglycine¹, Isoleucine⁸ Angiotensin II; Pentasarcosyl-AII; Angiotensin II (1-8) heptapeptide sarcosine analog; DRVYIHPF (sarcosine variant)
EINECS	Contact for details

Quality Control

Our Pentasarcosyl Angiotensin II is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to GMP principles for peptide synthesis, and our quality system supports compliance with relevant research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. This product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass spectrum consistent with molecular weight
Purity (HPLC)	≥ 95%
Assay (Content)	≥ 98% (on anhydrous basis)
Water Content (KF)	≤ 5.0%
Single Impurity (HPLC)	≤ 1.0%
Peptide Content	≥ 80%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.