Description

Indomethacin Acyl-B-D-Glucuronide is a major, pharmacologically relevant metabolite of the non-steroidal anti-inflammatory drug (NSAID) indomethacin. This compound is of critical importance for pharmaceutical research and development, particularly in the study of drug metabolism, pharmacokinetics, and the development of analytical reference standards. It is primarily utilized by research institutions, pharmaceutical companies, and contract research organizations (CROs) engaged in bioanalytical method development, metabolite identification, and regulatory safety testing.

Application

• Pharmaceutical Reference Standard: Serves as a certified reference material (CRM) for the quantitative and qualitative analysis of indomethacin and its metabolites in biological matrices.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Essential for investigating the metabolic pathways, clearance mechanisms, and bioavailability of indomethacin.
• Bioanalytical Method Development: Used to validate high-performance liquid chromatography (HPLC), liquid chromatography-mass spectrometry (LC-MS/MS), and other analytical methods for accurate metabolite detection.
• Toxicology and Safety Assessment: Employed in studies to understand the safety profile and potential toxicity of indomethacin metabolites.
• Clinical Research: Supports clinical trials by enabling precise monitoring of drug metabolite levels in patient samples.
• Impurity Profiling: Acts as a known impurity or degradation product standard for quality control in indomethacin API (Active Pharmaceutical Ingredient) manufacturing.

Basic Information

Product Name	Indomethacin Acyl-B-D-Glucuronide
CAS No.	75523-11-4
Molecular Formula	C31H32ClNO11
Molecular Weight	630.04 g/mol
Synonyms	1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid 1-β-D-glucopyranuronate; Indomethacin Acyl Glucuronide; Indomethacin 1-O-β-Acyl Glucuronide; Indomethacin β-1-O-Acyl Glucuronide; Indometacin Acyl Glucuronide; AI3-52300; SQ 19862 Glucuronide
EINECS	Contact for details

Quality Control

Our Indomethacin Acyl-B-D-Glucuronide is produced and handled under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, MS), to ensure it meets the high standards required for research and reference applications. A detailed Certificate of Analysis (COA) containing batch-specific data is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. For short-term use, the material may be stored at 2-8°C. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.