Description

Warfarin-D5 is a deuterated internal standard of the widely used anticoagulant, warfarin, where five hydrogen atoms are replaced with deuterium. This isotopic labeling is critical for ensuring accuracy and reliability in quantitative analytical methods. It is an essential reference material for researchers and quality control laboratories in the pharmaceutical and life sciences sectors requiring precise measurement of warfarin levels.

Application

• Quantitative Mass Spectrometry (MS): Serves as a stable isotope-labeled internal standard for the accurate quantification of warfarin in biological matrices (e.g., plasma, serum) using LC-MS/MS and GC-MS techniques.
• Pharmacokinetic and Bioavailability Studies: Enables precise tracking and measurement of warfarin absorption, distribution, metabolism, and excretion (ADME) in clinical and preclinical research.
• Therapeutic Drug Monitoring (TDM): Used in clinical laboratories to develop and validate robust assays for monitoring warfarin concentrations in patient blood samples to optimize dosage and minimize bleeding risks.
• Pharmaceutical Quality Control: Employed in the analysis of active pharmaceutical ingredients (APIs) and finished drug products to ensure potency, purity, and consistency.
• Metabolite Identification and Profiling: Aids in the identification and quantification of warfarin metabolites in complex biological systems.
• Forensic and Toxicology Analysis: Provides a reliable reference standard for the confirmatory analysis of warfarin in forensic investigations and toxicology screens.

Basic Information

Item	Detail
Product Name	Warfarin-D5
CAS No.	75472-93-4
Molecular Formula	C19H11D5O4
Molecular Weight	313.35 g/mol
Synonyms	4-Hydroxy-3-(3-oxo-1-phenylbutyl)-2H-1-benzopyran-2-one-d5; 3-(α-Acetonylbenzyl)-4-hydroxycoumarin-d5; Coumadin-d5; Marevan-d5; Jantoven-d5; Warfarin (phenyl-d5); Warfarin-d5 (Deuterated Internal Standard)
EINECS	Contact for details

Quality Control

Every batch of Warfarin-D5 is manufactured and analyzed under strict quality management protocols. We provide comprehensive analytical data to support its use as a high-purity reference standard. A detailed Certificate of Analysis (COA) is supplied with each shipment, reporting key parameters such as isotopic purity, chemical purity, and residual solvent content. Our quality systems are designed to meet the rigorous demands of analytical and regulatory laboratories.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (MS)	≥ 98.0 atom % D
Chemical Purity (NMR)	Conforms
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.