Description

Substance P (5-11), N,n-Dime-Gln(6)- CAS NO 75401-11-5 is a specific, biologically active fragment of the neuropeptide Substance P, modified with a dimethylglutamine residue at position 6. This compound is crucial for research in neuroscience and pharmacology, serving as a valuable tool for studying neurokinin-1 (NK-1) receptor interactions and signaling pathways. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and diagnostic developers focused on pain mechanisms, inflammation, and central nervous system disorders.

Application

• Neuroscience Research: A key reagent for investigating the role of Substance P in pain transmission, neurogenic inflammation, and neuronal communication.
• Pharmacological Studies: Used in receptor binding assays and functional studies to screen and characterize potential NK-1 receptor antagonists for drug discovery.
• Biochemical Analysis: Employed as a reference standard in analytical methods such as HPLC and mass spectrometry to quantify Substance P metabolites.
• Cell Signaling Pathways: Applied in cell-based assays to study intracellular signaling cascades activated by neurokinin receptors.
• Diagnostic Development: Serves as a critical component in the development of immunoassays and biosensors for detecting neuropeptide activity.

Basic Information

Product Name	Substance P (5-11), N,n-Dime-Gln(6)- CAS NO 75401-11-5
CAS No.	75401-11-5
Molecular Formula	C41H66N12O10S
Molecular Weight	895.1 g/mol
Synonyms	Substance P Fragment 5-11, [Glp5, Dime-Gln6]-Substance P (5-11); Pyr-Gln-Phe-Phe-Dime-Gln-Leu-Met-NH2; (5-11)-Substance P, N,N-dimethylglutamine6 analog; Neurokinin P (5-11) fragment; NK-1 receptor ligand fragment; SP (5-11); H-Pyr-Gln-Phe-Phe-Dime-Gln-Leu-Met-NH2
EINECS	Contact for details

Quality Control

Our Substance P (5-11), N,n-Dime-Gln(6)- is produced under stringent conditions to ensure the highest standards of purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot undergoes comprehensive analytical characterization, including HPLC purity analysis and mass spectrometry confirmation. A detailed Certificate of Analysis (COA) documenting identity, purity, and peptide content is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to theoretical mass
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Water Content (KF)	≤ 5.0%
Single Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.