Description

2-(Tetrahydro-2H-Pyran-2-Yl)Acetonitrile is a versatile nitrile-protected acetonitrile derivative, serving as a critical building block in advanced organic synthesis. Its primary value lies in its role as a protected form of cyanoacetic acid, enabling complex molecular construction while preventing unwanted side reactions. This high-purity intermediate is essential for research and production chemists in the pharmaceutical, agrochemical, and specialty chemical industries who require reliable, high-quality synthons for developing active ingredients and novel compounds.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of complex drug molecules, particularly those requiring the controlled introduction of a cyano or carboxylic acid functionality.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides where the tetrahydro-2H-pyranyl group acts as a protective moiety.
• Fine Chemical Manufacturing: Serves as a precursor for flavors, fragrances, and other specialty chemicals requiring precise synthetic pathways.
• Academic & R&D Laboratories: A valuable reagent for methodological development and the exploration of new chemical entities in organic chemistry research.
• Peptide & Polymer Chemistry: Employed in the synthesis of modified amino acids or as a monomer precursor for specialty polymers.

Basic Information

Product Name	2-(Tetrahydro-2H-Pyran-2-Yl)Acetonitrile
CAS No.	75394-84-2
Molecular Formula	C7H11NO
Molecular Weight	125.17 g/mol
Synonyms	2-(Oxan-2-yl)acetonitrile; THP-Acetonitrile; (Tetrahydro-2H-pyran-2-yl)acetonitrile; 2-(Tetrahydro-2H-pyran-2-yl)ethanenitrile; Acetonitrile, 2-(tetrahydro-2H-pyran-2-yl)-; 2-(Tetrahydropyran-2-yl)acetonitrile; 2-(2-Tetrahydropyranyl)acetonitrile; 75394-84-2
EINECS	Contact for details

Quality Control

Our 2-(Tetrahydro-2H-Pyran-2-Yl)Acetonitrile is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for sensitive synthetic applications. Each lot is analyzed using advanced chromatographic and spectroscopic techniques. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong oxidizing agents, strong acids, and strong bases. For long-term storage, consider maintaining under an inert atmosphere to preserve optimal quality.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Refractive Index (n20/D)	1.450 - 1.460
Density (g/mL at 20°C)	1.00 - 1.05

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.