Description

(-n-Desmethyl Tramadol is a key pharmaceutical intermediate and an active metabolite of the analgesic tramadol. This compound is of significant interest in research and development for its role in pharmacological studies and the synthesis of novel therapeutic agents. It is primarily utilized by pharmaceutical R&D laboratories, analytical reference standard producers, and manufacturers of active pharmaceutical ingredients (APIs) for advanced pain management solutions.

Application

• Pharmaceutical Intermediate: Critical building block in the synthesis of tramadol and related analgesic compounds.
• Analytical Reference Standard: Used as a high-purity standard in HPLC, LC-MS, and GC-MS for pharmacokinetic and bioequivalence studies.
• Metabolite Research: Essential for in vitro and in vivo studies investigating the metabolism, efficacy, and safety profile of tramadol.
• Active Pharmaceutical Ingredient (API) Development: Serves as a precursor in the development and scale-up of new analgesic formulations.
• Biochemical Research: Employed in studies targeting opioid receptors and understanding pain modulation pathways.
• Quality Control & Assurance: Used by API manufacturers for in-process testing and final product verification to ensure batch consistency.

Basic Information

Product Name	(-n-Desmethyl Tramadol
CAS No.	75377-45-6
Molecular Formula	C15H23NO2
Molecular Weight	249.35 g/mol
Synonyms	O-Desmethyltramadol; N-Desmethyl Tramadol; Desmethyltramadol; M1 Metabolite of Tramadol; (+)-O-Desmethyltramadol; (1R,2R)-2-[(Dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexanol; Tramadol Metabolite M1
EINECS	Contact for details

Quality Control

Our (-n-Desmethyl Tramadol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification, purity assay, and impurity profiling via advanced chromatographic techniques, to ensure it meets the stringent requirements for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.