Description

17-(Acetyloxy)-20-Oxo-6-Methylpregna-4,6-Dien-3-One [o-(Trimethylsilyl)Oxime] is a high-purity, specialized steroid derivative used as a critical synthetic intermediate in advanced pharmaceutical research and development. This compound matters because it provides a protected, reactive handle for the controlled synthesis of complex steroid-based molecules, enabling the exploration of novel therapeutic agents. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and biotechnology industries working on hormone modulators, anti-inflammatory drugs, and other steroid-related active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of novel steroid-based pharmaceuticals and active pharmaceutical ingredients (APIs).
• Research & Development: Used in medicinal chemistry for the design, synthesis, and structure-activity relationship (SAR) studies of new chemical entities targeting hormone receptors.
• Process Chemistry: Serves as a protected intermediate in the scale-up and optimization of synthetic routes for steroid drugs under Good Manufacturing Practice (GMP) conditions.
• Reference Standard: Employed as an analytical standard in quality control laboratories for method development and impurity profiling of related steroid compounds.
• Biochemical Research: Utilized in academic and industrial research to study steroid metabolism, enzyme inhibition, and receptor binding mechanisms.

Basic Information

Product Name	17-(Acetyloxy)-20-Oxo-6-Methylpregna-4,6-Dien-3-One [o-(Trimethylsilyl)Oxime]
CAS No.	75113-25-6
Molecular Formula	C27H41NO4Si
Molecular Weight	471.71 g/mol
Synonyms	6-Methylpregna-4,6-diene-3,20-dione, 17-(acetyloxy)-, O-(trimethylsilyl)oxime; 17α-Acetoxy-6-methyl-4,6-pregnadiene-3,20-dione O-(trimethylsilyl)oxime; 6-Methyl-17α-acetoxypregna-4,6-diene-3,20-dione (TMS oxime); Danazol TMS Oxime Derivative; Danazol Related Compound (TMS Oxime); Steroid TMS Oxime Intermediate.
EINECS	Contact for details

Quality Control

Our 17-(Acetyloxy)-20-Oxo-6-Methylpregna-4,6-Dien-3-One [o-(Trimethylsilyl)Oxime] is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring suitability for use in pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Any individual impurity ≤ 0.5%
Total Impurities	≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.