Description

E-1,1,1,5,5,5-Hexafluoro-4-(Trimethylsiloxy)-3-Pentene-2-One is a specialized fluorinated and silylated enone building block, valued for its unique reactivity profile. This compound serves as a critical intermediate in advanced organic synthesis, offering a versatile handle for introducing fluorinated moieties and silicon-protected functional groups. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing fluorinated active pharmaceutical ingredients (APIs) and drug candidates.
• Agrochemical Synthesis: Used in the production of novel fluorinated pesticides and herbicides, enhancing their biological activity and environmental stability.
• Advanced Material Precursor: Serves as a monomer or cross-linking agent in the development of specialty polymers, coatings, and fluorinated materials with unique surface properties.
• Organic Synthesis Reagent: Employed in Michael addition reactions, cycloadditions, and as a precursor for other fluorinated synthons in academic and industrial R&D.
• Liquid Crystal & Electronic Chemical: Potential use in the synthesis of fluorinated components for liquid crystal displays (LCDs) and organic electronic materials.

Basic Information

Product Name	E-1,1,1,5,5,5-Hexafluoro-4-(Trimethylsiloxy)-3-Pentene-2-One
CAS No.	75108-34-8
Molecular Formula	C8H8F6O2Si
Molecular Weight	278.22 g/mol
Synonyms	4-(Trimethylsiloxy)-1,1,1,5,5,5-hexafluoro-3-penten-2-one; 1,1,1,5,5,5-Hexafluoro-4-(trimethylsiloxy)-3-penten-2-one; (E)-4-(Trimethylsilyloxy)-1,1,1,5,5,5-hexafluoropent-3-en-2-one; Hexafluoroacetylacetone trimethylsilyl enol ether; HFA TMS enol ether; TMS enol ether of hexafluoroacetylacetone; 3-Penten-2-one, 1,1,1,5,5,5-hexafluoro-4-(trimethylsiloxy)-, (E)-
EINECS	Contact for details

Quality Control

Our E-1,1,1,5,5,5-Hexafluoro-4-(Trimethylsiloxy)-3-Pentene-2-One is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistent performance. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.