Description

cis-4-(Trifluoromethyl)Cyclohexanol is a high-value, chiral fluorinated organic intermediate with significant utility in advanced chemical synthesis. Its unique structure, featuring a cyclohexanol backbone with a cis-configured trifluoromethyl group, makes it a critical building block for creating molecules with tailored properties like enhanced metabolic stability and lipophilicity. This compound is essential for R&D and production in the pharmaceutical and agrochemical industries, where it is used to develop novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of active pharmaceutical ingredients (APIs), particularly in CNS and metabolic disease research.
• Agrochemical Synthesis: Used in the production of advanced herbicides and pesticides, where the trifluoromethyl group improves biological activity and environmental persistence.
• Liquid Crystal Materials: Serves as a precursor for fluorinated components in liquid crystal displays (LCDs), influencing dielectric anisotropy and viscosity.
• Advanced Material Science: Employed in the synthesis of specialty polymers and coatings to impart chemical resistance and low surface energy.
• Organic Synthesis & Catalysis: Acts as a versatile building block in asymmetric synthesis and as a ligand precursor in transition metal catalysis.
• Fluorine Chemistry Research: A valuable standard and reagent for studying the stereoelectronic effects of the CF3 group in cyclohexane systems.

Basic Information

Product Name	cis-4-(Trifluoromethyl)Cyclohexanol
CAS No.	75091-92-8
Molecular Formula	C7H11F3O
Molecular Weight	168.16 g/mol
Synonyms	4-(Trifluoromethyl)cyclohexanol, cis-Isomer; (1r,4r)-4-(Trifluoromethyl)cyclohexan-1-ol; cis-4-(Trifluoromethyl)-1-cyclohexanol; 4-(Trifluoromethyl)cyclohexanol (cis); rel-(1R,4R)-4-(Trifluoromethyl)cyclohexanol; NSC 405124; 75091-92-8
EINECS	Contact for details

Quality Control

Our cis-4-(Trifluoromethyl)Cyclohexanol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by GC/HPLC, to ensure it meets the high standards required for advanced synthetic applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Chiral Purity (cis-isomer)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.