Description

Gelonin From Gelonium Multiflorum is a potent ribosome-inactivating protein (RIP) derived from the seeds of the *Gelonium multiflorum* plant. This compound is a critical tool in biomedical research, particularly for its ability to inhibit protein synthesis by catalytically inactivating ribosomes. It is primarily utilized by researchers and developers in the biotechnology and pharmaceutical industries for constructing immunotoxins and targeted therapeutic conjugates, as well as for fundamental studies in cell biology and apoptosis.

Application

• Immunotoxin Conjugation: A key component in the development of antibody-drug conjugates (ADCs) and other targeted therapies for cancer research.
• Cell Biology Research: Used as a potent inhibitor of protein synthesis to study cellular mechanisms, ribosome function, and programmed cell death (apoptosis).
• Biochemical Tool: Employed in vitro to selectively deplete specific cell populations or to study the effects of protein synthesis inhibition on various cellular pathways.
• Drug Delivery Studies: Investigated in models for targeted drug delivery, leveraging its toxicity when internalized by specific cells.
• Plant Toxin Research: Serves as a reference standard in the study of ribosome-inactivating proteins (RIPs) and their mechanisms of action.

Basic Information

Product Name	Gelonin From Gelonium Multiflorum
CAS No.	75037-46-6
Molecular Formula	Contact for details
Molecular Weight	Approx. 30 kDa (Contact for details)
Synonyms	Gelonin; Gelonin Toxin; Ribosome-Inactivating Protein Gelonin; RIP Gelonin; *Gelonium multiflorum* Lectin; Type 1 Ribosome-Inactivating Protein; Protein Synthesis Inhibitor Gelonin
EINECS	Contact for details

Quality Control

Our Gelonin is produced and tested under stringent quality protocols. Each batch is characterized for activity and purity to ensure consistency for research applications. A comprehensive Certificate of Analysis (COA) is provided, detailing specifications such as biological activity, purity by SDS-PAGE and HPLC, and endotoxin levels. Our quality system is designed to support cGMP-compliant research and development.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (IR)	Conforms to reference standard
Purity (SDS-PAGE)	> 95%
Purity (HPLC)	> 90%
Biological Activity	Contact for details
Endotoxin Level	< 1.0 EU/μg
Protein Content	Determined by UV absorbance
Solubility	Soluble in water or PBS

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.