Description

(R)-(+)-2,2'-Bis[(Diphenylphosphino)Amino]-1,1'-Binaphthyl CAS NO 74974-14-4 is a high-value, chiral bisphosphine ligand widely recognized for its pivotal role in asymmetric catalysis. This compound matters because it enables the precise control of stereochemistry in critical bond-forming reactions, directly impacting the efficiency and yield of advanced chemical synthesis. It is essential for research and production chemists in the pharmaceutical, agrochemical, and fine chemical industries who require high enantioselectivity in hydrogenation and cross-coupling processes.

Application

• As a privileged chiral ligand for asymmetric hydrogenation of olefins, ketones, and imines in pharmaceutical intermediate synthesis.
• Catalyst component for enantioselective cross-coupling reactions, such as Suzuki-Miyaura and Heck reactions.
• Key reagent in the development of stereoselective synthetic methodologies for academic and industrial R&D.
• Used in the production of optically active agrochemicals and flavors & fragrances.
• Employed in homogeneous catalysis research for creating novel metal-ligand complexes.
• Critical for manufacturing single-enantiomer active pharmaceutical ingredients (APIs).

Basic Information

Product Name	(R)-(+)-2,2'-Bis[(Diphenylphosphino)Amino]-1,1'-Binaphthyl
CAS No.	74974-14-4
Molecular Formula	C52H40N2P2
Molecular Weight	754.84 g/mol
Synonyms	(R)-BINAP-Amine; (R)-(+)-2,2'-Bis[(Diphenylphosphino)Amino]-1,1'-Binaphthyl; (R)-2,2'-Bis[(Diphenylphosphino)Amino]-1,1'-Binaphthyl; (R)-BINAP-NH2; (R)-Bis[(Diphenylphosphino)Amino]binaphthyl; (R)-BINAP-amine ligand; (R)-BINAP-A; (R)-BINAP-NH2
EINECS	Contact for details

Quality Control

Every batch of our (R)-(+)-2,2'-Bis[(Diphenylphosphino)Amino]-1,1'-Binaphthyl undergoes rigorous analytical testing to ensure high chemical purity and chiral integrity, critical for catalytic performance. Our quality assurance protocols are designed to meet the stringent requirements of process chemistry and GMP environments. A comprehensive Certificate of Analysis (COA) detailing purity, enantiomeric excess, and identity is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C to minimize oxidation and ensure long-term stability. The storage area should be cool, dry, and well-ventilated. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	Off-white to light yellow powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (HPLC)	≥ 99.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.