Description

(R)-(-)-n-(3,5-Dinitrobenzoyl)-α-Phenylglycine is a high-purity chiral derivatizing agent and analytical reagent. Its primary value lies in its role as a key chiral selector for the resolution of enantiomers via high-performance liquid chromatography (HPLC). This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries who require precise enantiomeric separation for quality control, method development, and chiral synthesis.

Application

• Chiral Stationary Phase (CSP) Precursor: Used in the synthesis of Pirkle-type HPLC columns for enantiomeric separation.
• Chiral Derivatizing Agent (CDA): For converting enantiomeric mixtures into diastereomers for analysis by conventional HPLC or NMR.
• Pharmaceutical R&D: Critical for the analysis and purification of chiral drug intermediates and active pharmaceutical ingredients (APIs).
• Analytical Method Development: Serves as a standard and reference material for developing and validating chiral assay methods.
• Asymmetric Synthesis: Can be employed as a chiral auxiliary or building block in stereoselective synthesis.
• Quality Control Labs: Used to ensure enantiomeric purity of chiral compounds in compliance with regulatory standards.

Basic Information

Product Name	(R)-(-)-n-(3,5-Dinitrobenzoyl)-α-Phenylglycine
CAS No.	74927-72-3
Molecular Formula	C15H11N3O7
Molecular Weight	345.27 g/mol
Synonyms	(R)-N-(3,5-Dinitrobenzoyl)-α-phenylglycine; (R)-DNBPG; (R)-(-)-N-3,5-Dinitrobenzoyl-α-phenylglycine; (R)-α-Phenylglycine N-(3,5-dinitrobenzoyl) derivative; DNB-Phe-Gly-OH (R)-form; Pirkle Reagent (R)-isomer; Chiral Derivatization Reagent for HPLC; (R)-DNB-PG
EINECS	Contact for details

Quality Control

Our (R)-(-)-n-(3,5-Dinitrobenzoyl)-α-Phenylglycine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for analytical and research applications. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and specific rotation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	Yellow to light yellow crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Specific Rotation [α]	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.