Description

Aldosterone, Bis(o-Trimethylsilyl-) is a silylated derivative of the important mineralocorticoid hormone aldosterone. This chemical modification enhances the compound's stability and volatility, making it a critical analytical standard and intermediate in sophisticated chemical synthesis. It is primarily utilized by research institutions and pharmaceutical companies engaged in steroid hormone analysis, method development, and high-purity chemical manufacturing. The product, identified by CAS No. 74915-86-9, is supplied to meet the stringent requirements of advanced laboratory and production environments.

Application

• Gas Chromatography-Mass Spectrometry (GC-MS) Internal Standard: Serves as a stable, volatile derivative for the precise quantification of aldosterone and related steroids in biological matrices.
• Liquid Chromatography (LC-MS/MS) Reference Material: Used for method validation and calibration in clinical research and diagnostic assay development.
• Pharmaceutical Intermediate: Acts as a protected synthetic precursor in the research-scale production of novel steroid-based therapeutics or labeled compounds.
• Metabolomics and Endocrine Research: Essential for profiling steroid hormones in studies of hypertension, adrenal disorders, and metabolic pathways.
• Quality Control & Method Development: Employed by analytical laboratories and CROs to develop, optimize, and validate regulatory-compliant testing protocols.
• Chemical Derivatization Agent: Used in sample preparation to improve the chromatographic behavior and detection sensitivity of hydroxyl-containing steroids.

Basic Information

Product Name	Aldosterone, Bis(o-Trimethylsilyl-)
CAS No.	74915-86-9
Molecular Formula	C30H52O5Si2
Molecular Weight	548.9 g/mol
Synonyms	11β,21-Dihydroxy-3,20-dioxopregn-4-en-18-al Bis(O-trimethylsilyl) Derivative; Aldosterone Bis(trimethylsilyl) Ether; Aldosterone Di-TMS; 18-Formyl-11β,21-dihydroxy-3,20-dioxopregn-4-en-18-al Bis(trimethylsilyl ether); Aldosterone Bis(TMS) Ether; Aldosterone Di(trimethylsilyl) Derivative
EINECS	Contact for details

Quality Control

Every batch of Aldosterone, Bis(o-Trimethylsilyl-) is manufactured and analyzed under strict quality management systems to ensure identity, purity, and consistency. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request, providing detailed results for key parameters such as assay purity and identity confirmation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.