Description

trans-10-Hydroxy Nortriptyline is a key pharmaceutical intermediate and metabolite of the tricyclic antidepressant nortriptyline. This compound is of significant importance for research and development in neuropharmacology and analytical chemistry. It is primarily utilized by pharmaceutical manufacturers and research institutions for drug metabolism studies, analytical reference standards, and the synthesis of novel therapeutic agents.

Application

• Primary reference standard for the analytical quantification of nortriptyline and its metabolites in biological matrices.
• Critical intermediate in the research and development of novel tricyclic antidepressant compounds and their derivatives.
• Essential material for pharmacokinetic and pharmacodynamic studies to understand drug metabolism pathways.
• Used in clinical research and forensic toxicology for method development and validation.
• Key starting material or building block in organic synthesis for specialized fine chemical production.
• Utilized in stability studies and impurity profiling for pharmaceutical quality control.

Basic Information

Product Name	trans-10-Hydroxy Nortriptyline
CAS No.	74853-74-0
Molecular Formula	C19H23NO
Molecular Weight	281.39 g/mol
Synonyms	(10R,11R)-10,11-Dihydro-10-hydroxy-5H-dibenzo[a,d]cyclohepten-5-ylidene-N-methylmethanaminium; 10-Hydroxynortriptyline (trans- isomer); (E)-10-Hydroxynortriptyline; trans-10-Hydroxynortriptyline; 10-OH-NT; Nortriptyline Metabolite E
EINECS	Contact for details

Quality Control

Our trans-10-Hydroxy Nortriptyline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and related substances is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.