Description

β-Nadph-D CAS NO 74784-45-5 is the reduced, deuterated form of nicotinamide adenine dinucleotide phosphate (NADPH), a critical coenzyme in numerous biochemical redox reactions. This deuterated analog is essential for advanced research and development, particularly in mechanistic studies and analytical applications where isotopic labeling is required. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies specializing in enzymology, metabolic pathway analysis, and high-precision mass spectrometry.

Application

• Isotopic Tracer Studies: Used as a deuterium-labeled cofactor to trace hydride transfer mechanisms in enzymatic reactions, providing insights into reaction pathways.
• Metabolic Research: Employed in in vitro assays to study NADPH-dependent pathways, including lipid biosynthesis, cholesterol metabolism, and detoxification processes.
• Analytical Reference Standard: Serves as a high-purity internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS) and Nuclear Magnetic Resonance (NMR) for the quantitative analysis of biological samples.
• Pharmaceutical Development: Applied in drug discovery for screening and characterizing enzymes like cytochrome P450s, dehydrogenases, and reductases that are key drug targets.
• Biocatalysis: Utilized as a coenzyme in enzymatic synthesis and bioreduction processes to produce chiral intermediates for fine chemicals and active pharmaceutical ingredients (APIs).

Basic Information

Product Name	β-Nadph-D CAS NO 74784-45-5
CAS No.	74784-45-5
Molecular Formula	C21D2H27N7O17P3
Molecular Weight	~747.4 g/mol (deuterated form)
Synonyms	β-NADPH-d2; Deuterated NADPH; Tetrasodium 2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) adenosine 5'-ester with 1,4-dihydro-1-(2-D,3-D-2,3,4,5,6-pentahydroxy-6-oxo-1-hexyl)-3-carbamoylpyridinium, inner salt; Reduced Nicotinamide Adenine Dinucleotide Phosphate-d2; β-NADPH (reduced, deuterated); TPNH-d2; Coenzyme II-d2
EINECS	Contact for details

Quality Control

Our β-Nadph-D is manufactured under strict quality systems to ensure high chemical purity and isotopic enrichment suitable for research applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as purity (by HPLC), isotopic purity (deuterium content), and identification. We adhere to relevant industry guidelines to ensure product integrity and batch-to-batch consistency for your critical research needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to minimize oxidation. The product is light-sensitive and easily oxidized; prolonged exposure to air, light, or elevated temperatures should be avoided. Allow the vial to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Isotopic Purity (deuterium content)	≥ 98 atom % D
Water Content (KF)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.