Description

Moc-Leu-Oh CAS NO 74761-37-8 is a protected amino acid derivative, specifically the methyloxycarbonyl (Moc) derivative of L-leucine. This compound is a crucial building block in solid-phase peptide synthesis (SPPS), where it serves to protect the amine functionality of leucine, enabling the controlled and sequential assembly of complex peptide chains. It is an essential raw material for research institutions, pharmaceutical developers, and fine chemical manufacturers engaged in the production of therapeutic peptides, biochemical probes, and novel materials.

Application

• Solid-Phase Peptide Synthesis (SPPS): A fundamental Nα-protected amino acid for the Fmoc/t-Bu strategy, enabling the incorporation of leucine residues.
• Pharmaceutical Intermediates: Serves as a key precursor in the research and development of peptide-based drugs, including hormones, antibiotics, and enzyme inhibitors.
• Biochemical Research: Used in academic and industrial labs for synthesizing custom peptides for structure-activity relationship (SAR) studies, epitope mapping, and protein-protein interaction analysis.
• Combinatorial Chemistry: Employed in the generation of diverse peptide libraries for high-throughput screening in drug discovery programs.
• Fine Chemical Production: Acts as a specialized intermediate for the synthesis of more complex, leucine-containing chiral molecules and conjugates.

Basic Information

Product Name	Moc-Leu-Oh
CAS No.	74761-37-8
Molecular Formula	C9H17NO4
Molecular Weight	203.24 g/mol
Synonyms	N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-leucine; Fmoc-L-leucine; (S)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-4-methylpentanoic acid; Fmoc-Leu-OH; N-Fmoc-L-leucine; N-α-Fmoc-L-leucine; L-Leucine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-; NSC 334284
EINECS	Contact for details

Quality Control

Our Moc-Leu-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and identity confirmation via IR and NMR spectroscopy. We provide Certificates of Analysis (COA) with each shipment, detailing all critical parameters to ensure compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.5%
Optical Rotation [α]D20	-15.0° to -17.0° (c=1 in DMF)
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.