Description

Bis(2,2-Dimethylpropyl)[2(Or 5)-Methyl-5(Or 2)-(1-Methylethyl)Cyclohexyl]Phosphine is a specialized, sterically hindered tertiary phosphine ligand, a key component in advanced catalytic systems. Its unique structure, featuring neopentyl and bulky menthyl-derived substituents, is engineered to provide exceptional stability and selectivity in transition metal catalysis. This high-value ligand is essential for researchers and manufacturers in the pharmaceutical and fine chemical industries developing novel synthetic routes, particularly for asymmetric hydrogenation and cross-coupling reactions.

Application

• As a chiral ligand in asymmetric hydrogenation reactions for the synthesis of enantiomerically pure pharmaceutical intermediates.
• As a stabilizing ligand in homogeneous catalysis, enhancing catalyst lifetime and performance in cross-coupling reactions (e.g., Suzuki, Heck).
• In the development of novel organometallic complexes for academic and industrial research in catalysis.
• For the synthesis of high-value agrochemicals and specialty chemicals requiring precise stereochemical control.
• As a key component in catalyst screening libraries for process chemistry optimization in fine chemical production.

Basic Information

Product Name	Bis(2,2-Dimethylpropyl)[2(Or 5)-Methyl-5(Or 2)-(1-Methylethyl)Cyclohexyl]Phosphine
CAS No.	74753-31-4
Molecular Formula	C19H39P
Molecular Weight	298.49 g/mol
Synonyms	Bis(neopentyl)menthylphosphine; (1R,2S,5R)-Menthylbis(neopentyl)phosphine; (1R,2S,5R)-2-Isopropyl-5-methylcyclohexylbis(2,2-dimethylpropyl)phosphine; Neopentyl-Menthyl-Phosphine (NMP); P(Menthyl)(CH2C(CH3)3)2; (1-Menthyl)bis(neopentyl)phosphine; Ligand for asymmetric hydrogenation
EINECS	Contact for details

Quality Control

Every batch of our Bis(2,2-Dimethylpropyl)[2(Or 5)-Methyl-5(Or 2)-(1-Methylethyl)Cyclohexyl]Phosphine is synthesized and purified under stringent, inert conditions to prevent oxidation. We employ advanced analytical techniques including NMR (1H, 13C, 31P) and chiral HPLC to ensure high chemical and enantiomeric purity. A comprehensive Certificate of Analysis (COA) detailing identity, assay, and impurity profiles is provided with each shipment, supporting cGMP-compliant applications in pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store under an inert atmosphere (argon or nitrogen) at 2-8°C. This compound is easily oxidized; containers should be flushed with inert gas after each opening to maintain purity. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.