Description

Insulin, Phe(A19)- CAS NO 74665-98-8 is a chemically modified insulin analogue where the amino acid at position A19 is substituted with phenylalanine. This specific modification is of significant interest in pharmaceutical research and development, particularly for studying insulin's structure-activity relationships and receptor binding mechanisms. It is a critical reagent for academic institutions, biotechnology firms, and pharmaceutical companies engaged in metabolic disease research, novel therapeutic design, and biochemical assay development.

Application

• Biochemical Research: Used as a reference standard and tool compound for investigating insulin signaling pathways and metabolism.
• Pharmaceutical Development: Serves as a key intermediate or model compound in the R&D of novel insulin analogues and diabetes therapeutics.
• Structure-Activity Relationship (SAR) Studies: Essential for mapping the functional domains of insulin and understanding the impact of specific amino acid substitutions.
• Receptor Binding Assays: Employed in competitive binding studies to characterize insulin receptor affinity and kinetics.
• Quality Control & Analytical Standards: Used as a high-purity standard in HPLC, MS, and other analytical methods for insulin-related quality testing.
• Educational & Diagnostic Tool: Utilized in advanced life science education and in the development of diagnostic assays for insulin and related biomarkers.

Basic Information

Product Name	Insulin, Phe(A19)- CAS NO 74665-98-8
CAS No.	74665-98-8
Molecular Formula	C257H383N65O77S6
Molecular Weight	5807.9 g/mol (approx.)
Synonyms	Phe(A19)-Insulin; Insulin (Phe-A19); A19-Phenylalanine Insulin; [PheA19]-Insulin; Insulin analogue (A19Phe); Insulin, A19-Phe substituted; [Phenylalanine-A19]-Insulin
EINECS	Contact for details

Quality Control

Our Insulin, Phe(A19)- is produced and handled under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and mass spectrometry for identity confirmation, to ensure it meets the high standards required for research applications. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting purity, potency, and other critical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake. For long-term storage, keep desiccated at -20°C.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Peptide Content	≥ 80.0% (by weight)
Water Content (KF)	≤ 5.0%
Biological Activity	Assessed by receptor binding assay (Data available)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.