Description

cis-2-Cyanocyclopropane-1-Carboxylic Acid is a high-value, multifunctional cyclopropane derivative featuring both nitrile and carboxylic acid functional groups on the strained three-membered ring. This unique molecular architecture makes it a critical chiral building block and versatile synthon for advanced organic synthesis. It is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing complex, bioactive molecules.

Application

• Pharmaceutical Intermediate: A key chiral precursor for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in the development of protease inhibitors, antiviral agents, and other therapeutics where the cyclopropane ring confers metabolic stability.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the strained ring system can enhance biological activity and environmental profile.
• Ligand and Catalyst Development: Serves as a starting material for creating novel chiral ligands and organocatalysts used in asymmetric synthesis to control stereochemistry.
• Material Science Research: Employed in the synthesis of specialized monomers and polymers with unique thermal or mechanical properties derived from the rigid cyclopropane structure.
• Chemical Biology Probes: Utilized to build molecular probes and tags for studying enzyme mechanisms and biological pathways due to its reactive handles.
• Custom Synthesis & Contract Manufacturing: A fundamental building block for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	cis-2-Cyanocyclopropane-1-Carboxylic Acid
CAS No.	74650-11-6
Molecular Formula	C5H5NO2
Molecular Weight	111.10 g/mol
Synonyms	(1R,2S)-2-Cyanocyclopropanecarboxylic Acid; (1S,2R)-2-Cyanocyclopropanecarboxylic Acid; cis-2-Cyanocyclopropanecarboxylic Acid; 2-Cyano-cis-cyclopropanecarboxylic Acid; 1-Cyclopropanecarboxylic acid, 2-cyano-, cis-; (+/-)-cis-2-Cyanocyclopropanecarboxylic Acid; rac-cis-2-Cyanocyclopropanecarboxylic Acid
EINECS	Contact for details

Quality Control

Our cis-2-Cyanocyclopropane-1-Carboxylic Acid is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with each shipment, which include data from HPLC, NMR, and other relevant spectroscopic methods. Our commitment to reliable supply and batch-to-batch consistency supports your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). The compound is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere if necessary to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.